TITLE

Who does not need a statin: too late in end-stage renal disease or heart failure?

AUTHOR(S)
Laufs, U.; Custodis, F.; Böhm, M.
PUB. DATE
September 2008
SOURCE
Heart;Sep2008, Vol. 94 Issue 9, p1138
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Current guidelines from large randomised trials recommend that all patients with diabetes type 2 or coronary artery disease after myocardial infarction should be treated with statin drugs. However, the recent 4D and CORONA trials show no improvement in mortality in elderly patients with ischaemic heart failure and patients with diabetes and end-stage renal disease receiving haemodialysis with the onset of statin treatment. The survival benefit from statin treatment appears to stem primarily from the prevention of progression of coronary artery disease. In clinical conditions where coronary artery disease does not significantly contribute to the cause of death statins seem to be less effective. In patients at risk for organ damage, statin treatment, therefore, has to be started early in the course of the disease. The effect of statin withdrawal in ischaemic heart failure or in patients with advanced renal disease is not known. On the basis of the available evidence, current statin treatment should not be stopped in these patients.
ACCESSION #
34293199

 

Related Articles

  • Reduced Risk of Incident AD with Elective Statin Use in a Clinical Trial Cohort. Sparks, D. L.; Kryscio, Richard J.; Sabbagh, Marwan N.; Connor, Donald J.; Sparks, Lisa M.; Liebsack, Carolyn // Current Alzheimer Research;Oct2008, Vol. 5 Issue 4, p416 

    Statins have been reported to reduce the risk and be of benefit in the treatment of Alzheimer's disease (AD). Individuals enrolling in the randomized controlled trial testing two anti-inflammatory agents for primary prevention of AD (Alzheimer's Disease Anti-inflammatory Prevention Trial; ADAPT)...

  • Estimating treatment effects for individual patients based on the results of randomised clinical trials. Dorresteijn, Johannes A. N.; Visseren, Frank L. J.; Ridker, Paul M.; Wassink, Annemarie M. J.; Paynter, Nina P.; Steyerberg, Ewout W.; van der Graaf, Yolanda; Cook, Nancy R. // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;10/22/2011, Vol. 343 Issue 7828, p836 

    No abstract available.

  • Statine nach abgesetzter Therapie meist wieder gut toleriert. Steurer, Johann // Praxis (16618157);6/19/2013, Vol. 102 Issue 13, p813 

    No abstract available.

  • Effects of Lipophilic Statins for Heart Failure: A Meta-analysis of 13 Randomised Controlled Trials. Liu, Gang; Zheng, Xin-Xin; Xu, Yan-Lu; Lu, Jie; Hui, Ru-Tai; Huang, Xiao-Hong // Heart, Lung & Circulation;Oct2014, Vol. 23 Issue 10, p970 

    Background The effects of lipophilic statins in heart failure (HF) were controversial. The goal of the present study was to systematically review all randomised controlled trials evaluating the effects of lipophilic statins in patients with HF. Methods We performed a comprehensive literature...

  • Cardiovascular Disease and Dyslipidemia: Beyond LDL. P�ss*, Janine; Custodis, Florian; Werner, Christian; Weing�rtner, Oliver; B�hm, Michael; Laufs, Ulrich // Current Pharmaceutical Design;3/21/2011, Vol. 17 Issue 9, p861 

    No abstract available.

  • Statin Therapy May Influence the Incidence of Postoperative Atrial Fibrillation. Saso, Srdjan; Vecht, Joshua A.; Rao, Christopher; Protopapas, Aristotle; Ashrafian, Hutan; Leff, Daniel; Darzi, Ara; Athanasiou, Thanos // Texas Heart Institute Journal;2009, Vol. 36 Issue 6, p521 

    Atrial fibrillation is the most common postoperative arrhythmia in patients who undergo cardiac surgery. We sought to determine whether the administration of statins reduces the incidence of postoperative atrial fibrillation in cardiac surgery patients. We performed a meta-analysis on all...

  • The efficiency of cardiovascular risk assessment: do the right patients get statin treatment? van Staa, Tjeerd-Pieter; Smeeth, Liam; Ng, Edmond S-W; Goldacre, Ben; Gulliford, Martin // Heart;Nov2013, Vol. 99 Issue 21, p1597 

    Objective To evaluate targeting of statin prescribing for primary prevention to those with high cardiovascular disease (CVD) risk. Design Two cohort studies including the general population and initiators of statins aged 35-74 years. Setting UK primary care records in the Clinical Practice...

  • Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. Macedo, Ana Filipa; Taylor, Fiona Claire; Casas, Juan P.; Adler, Alma; Prieto-Merino, David; Ebrahim, Shah // BMC Medicine;2014, Vol. 12 Issue 1, p1 

    Background Efficacy of statins has been extensively studied, with much less information reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on unintended effects is often insufficient to support hypotheses generated from observational studies. We aimed to...

  • Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial. Whitehorn, James; Chau Van Vinh Nguyen; Lam Phung Khanh; Duong Thi Hue Kien; Nguyen Than Ha Quyen; Nguyen Thi Thanh Tran; Nguyen Thuy Hang; Nguyen Thanh Truong; Luong Thi Hue Tai; Nguyen Thi Cam Huong; Vo Thanh Nhon; Ta Van Tram; Farrar, Jeremy; Wolbers, Marcel; Simmons, Cameron P.; Wills, Bridget // Clinical Infectious Diseases;2/15/2016, Vol. 62 Issue 4, p468 

    Background. Dengue endangers billions of people in the tropical world, yet no therapeutic is currently available. In part, the severe manifestations of dengue reflect inflammatory processes affecting the vascular endothelium. In addition to lipid lowering, statins have pleiotropic effects that...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics