Chemotherapy: CNS Stem-cell Killer

Johnston, S. Laurence
October 2008
PN;Oct2008, Vol. 62 Issue 10, p32
Trade Publication
The article discusses the study by Dr. Mark Noble and his colleagues on the effects of chemotherapy on stem and progenitor cells in the central nervous system (CNS). They used common drugs on the progenitor cells found in the CNS and in mice. They found out that progenitor cells were sensitive to neurotoxicity and that chemotherapy changes cell composition. This was further supported by the in vivo toxicity testing in mice. The sensitivity of neural precursor cells to radiation is also cited.


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