TITLE

Chemotherapy: CNS Stem-cell Killer

AUTHOR(S)
Johnston, S. Laurence
PUB. DATE
October 2008
SOURCE
PN;Oct2008, Vol. 62 Issue 10, p32
SOURCE TYPE
Trade Publication
DOC. TYPE
Article
ABSTRACT
The article discusses the study by Dr. Mark Noble and his colleagues on the effects of chemotherapy on stem and progenitor cells in the central nervous system (CNS). They used common drugs on the progenitor cells found in the CNS and in mice. They found out that progenitor cells were sensitive to neurotoxicity and that chemotherapy changes cell composition. This was further supported by the in vivo toxicity testing in mice. The sensitivity of neural precursor cells to radiation is also cited.
ACCESSION #
34284466

 

Related Articles

  • Radioimmunotherapy of mice bearing breast tumors with 177Lu-labeled trastuzumab. RASANEH, Samira; RAJABI, Hossein; AKHLAGHPOOR, Shahram; SHEYBANI, Shahab // Turkish Journal of Medical Sciences;SUP2012, Vol. 42 Issue S1, p1292 

    Aim: In the present study, we investigated the therapeutic efficacy of trastuzumab labeled with lutetium-177 (177Lu) in mice bearing breast tumors. Materials and methods: Trastuzumab was labeled with 177Lu via D OTA as a chelator. In vitro and in vivo quality control tests of incorporated...

  • Acute and Sub-chronic Toxicity Studies of Crude Aqueous Extract of Albizzia chevalieri Harms (Leguminosae). Saidu, Y.; Bilbis, L. S.; Lawal, M.; Isezuo, S. A.; Hassan, S. W.; Abbas, A. Y. // Asian Journal of Biochemistry;2007, Vol. 2 Issue 4, p224 

    The current study reports the toxicological studies of the crude aqueous leaf extract using albino rat models. The in vivo effects of acute and sub-chronic doses of the extract on liver function and kidney function and kidney function parameters were studied. The results indicated that the...

  • Anti-inflammatory activity of aqueous extract of Cinnamomum tamala leaves by in vivo and in vitro methods. Gambhire, Manoj Nilkant; Juvekar, Archana Ramesh; Shaijesh Shirish Wankhede // Journal of Pharmacy Research;Sep2009, Vol. 2 Issue 9, p1521 

    Cinnamomum tamala (Family- Lauraceae) was used traditionally in the treatment of inflammation but there is no scientific evidence exists to validate the folkloric use of the plant. Thus the present work was aimed at investigating the anti-inflammatory effect of the aqueous extract of Cinnamomum...

  • Anticancer Effect of Plant-Derived Polysaccharides on Mice. Wenfeng Huang // Journal of Cancer Therapy;Apr2013, Vol. 4 Issue 2, p500 

    Tupistra chinensis is a widely used medicinal plant in Hubei Province, China. In our study, we investigated the effect of polysaccharides component from Tupistra chinensis on mice in vivo. The mice H22 hepatocarcinoma animal model was established firstly. Then, the mice were fed with different...

  • © RELATIONSHIP BETWEEN TUMOUR RESISTANCE AND THE IN VITRO AND IN VIVO CYTOTOXICITY ELICITED BY SALMONELLA ANTIGENS IN IMMUNIZED MICE. Ashley, Michael P.; Kotlarski, Ieva // Australian Journal of Experimental Biology & Medical Science;Dec1982, Vol. 60 Issue 6, p663 

    The article analyzes the relationship between tumor resistance and the in vitro and in vivo cytotoxicity elicited by salmonella antigens in immunized mice. Intracellular parasites induce resistance to immunologically unrelated microbial pathogens and tumors. Tumor resistance was strongly...

  • Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility. Yuhong Bai; Yi Zhang; Jingping Zhang; Qingxin Mu; Weidong Zhang; Butch, Elizabeth R.; Snyder, Scott E.; Bing Yan // Nature Nanotechnology;Sep2010, Vol. 5 Issue 9, p683 

    Soluble carbon nanotubes show promise as materials for in vivo delivery and imaging applications. Several reports have described the in vivo toxicity of carbon nanotubes, but their effects on male reproduction have not been examined. Here, we show that repeated intravenous injections of...

  • ETHANOL INDUCED HEPATIC STEATOSIS - MORPHO - FUNCTIONAL ASPECTS. Tutunaru, Dana; Ciocoiu, Manuela; Coman, Malina; Musat, Carmina; Nechita, A.; Badescu, Magda // Annals of the Romanian Society for Cell Biology;2010, Vol. 15 Issue 2, p362 

    In this study, we obtained an experimental model to assess potential toxic effects of alcohol, with the beneficial effects of alcohol association with soluble salts of zinc or vegetal polyphenols. The research was conducted on white Wistar mice, divided into four groups of 15 animals each: Group...

  • Negative regulation of the deacetylase SIRT1 by DBC1. Wenhui Zhao; Kruse, Jan-Philipp; Yi Tang; Sung Yun Jung; Jun Qin; Wei Gu // Nature;1/31/2008, Vol. 451 Issue 7178, p587 

    SIRT1 is an NAD-dependent deacetylase critically involved in stress responses, cellular metabolism and, possibly, ageing. The tumour suppressor p53 represents the first non-histone substrate functionally regulated by acetylation and deacetylation; we and others previously found that SIRT1...

  • Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo. Marraco, Silvia A. Fuertes; Scott, Clare L.; Bouillet, Philippe; Ives, Annette; Masina, Slavica; Vremec, David; Jansen, Elisa S.; O'Reilly, Lorraine A.; Schneider, Pascal; Fasel, Nicolas; Shortman, Ken; Strasser, Andreas; Acha-Orbea, Hans // PLoS ONE;2011, Vol. 6 Issue 6, p1 

    Background: DC are activated by pathogen-associated molecular patterns (PAMPs), and this is pivotal for the induction of adaptive immune responses. Thereafter, the clearance of activated DC is crucial to prevent immune pathology. While PAMPs are of major interest for vaccine science due to their...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics