TITLE

Exaggeration of treatment benefits using the "event-based" number needed to treat

AUTHOR(S)
Aaron, Shawn D.; Fergusson, Dean A.
PUB. DATE
September 2008
SOURCE
CMAJ: Canadian Medical Association Journal;9/23/2008, Vol. 179 Issue 7, p669
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses the population needed to asses the effects of medications within a specified time frame in a clinical trial. However, on 2005, a new approach was proposed, which became the basis of examination of respiratory diseases, wherein the population depends on the events that may happen within the medication period. It notes that recent trials reveals the rate of aggravation of chronic obstructive pulmonary disease by 0.92 per patient per year who are under corticosteroids medication including fluticasone and salmeterol. Nonetheless, the experiment cannot give a general conclusion because some patients suffer from relapses unlike the constant flow of events during the medication period of the performed trial.
ACCESSION #
34283305

 

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