Exaggeration of treatment benefits using the "event-based" number needed to treat

Aaron, Shawn D.; Fergusson, Dean A.
September 2008
CMAJ: Canadian Medical Association Journal;9/23/2008, Vol. 179 Issue 7, p669
Academic Journal
The article discusses the population needed to asses the effects of medications within a specified time frame in a clinical trial. However, on 2005, a new approach was proposed, which became the basis of examination of respiratory diseases, wherein the population depends on the events that may happen within the medication period. It notes that recent trials reveals the rate of aggravation of chronic obstructive pulmonary disease by 0.92 per patient per year who are under corticosteroids medication including fluticasone and salmeterol. Nonetheless, the experiment cannot give a general conclusion because some patients suffer from relapses unlike the constant flow of events during the medication period of the performed trial.


Related Articles

  • A Comparison of Two Regimens of Topical Corticosteroids in the Treatment of Patients with Bullous Pemphigoid: A Multicenter Randomized Study. Joly, Pascal; Roujeau, Jean-Claude; Benichou, Jacques; Delaporte, Emmanuel; D'Incan, Michel; Dreno, Brigitte; Bedane, Christophe; Sparsa, Agnes; Gorin, Isabelle; Picard, Catherine; Tancrede-Bohin, Emmanuelle; Sassolas, Bruno; Lok, Catherine; Guillaume, Jean-Claude; Doutre, Marie-Sylvie; Richard, Marie-Aleth; Caux, Frédéric; Prost, Catherine; Plantin, Patrice; Chosidow, Olivier // Journal of Investigative Dermatology;Jul2009, Vol. 129 Issue 7, p1681 

    Superpotent topical corticosteroids (CS) have been demonstrated to improve bullous pemphigoid (BP) patients’ survival. We assessed whether a mild regimen using lower doses of topical CS and a shorter duration could improve the outcome of BP patients even more. Three-hundred and twelve BP...

  • Giving patients a voice. Frembes, Linda Seid // Expo Magazine;Jul/Aug2008, Vol. 20 Issue 7, p38 

    The article focuses on the Patient Advisory Roundtable (PAR) created by the American Thoracic Society (ATS) in 2001 to facilitate patient involvement in its annual conferences. It cites that PAR is comprised of 15 patient groups that advocate for respiratory patients and their families and...

  • Single-dose dexamethasone for mild croup. Chambers, Christopher V.; Russell, John J. // Patient Care;Dec2004, Vol. 38 Issue 12, p72 

    Discusses research being done on single-dose of oral dexamethasone for mild croup. Reference to a study by C. L. Bjorson et al published in the 2004 issue of the "New England Journal of Medicine"; Explanation on corticosteroids; Findings of the study.

  • American Thoracic Society Intl Conference Long-term ICS use reduces pleural effusion in patients with CAP.  // Biomedical Market Newsletter;6/1/2012, Vol. 21, p1 

    The article focuses on a study according to which prior treatment with inhaled corticosteroids in patients with respiratory disorders who develop community acquired pneumonia (CAP) is associated with a lower incidence and severity of parapneumonic effusion.

  • Reversing Lung Collapse and Hypoxemia in Early ARDS. Pierson, David J. // Critical Care Alert;Jan2007, Vol. 14 Issue 10, p75 

    Borges and colleagues in sao palo, brazil, studied 26 patients with acute lung injury or the acute respiratory distress syndrome (ARDS) to determine whether atelectatic lung areas could be fully recruited and oxygenation improved using a protocol employing progressively higher levels of positive...

  • Make your own health miracle. MacMillan, Amanda // Prevention;Dec2006, Vol. 58 Issue 12, p139 

    The article presents information about participating in experimental trials across the U.S. including the National Institutes of Health Clinical Center in Bethesda, Maryland. Prevention trials look for better ways to keep people healthy, diagnostic and screening clinical trials look for methods...

  • A prospective randomized, double-blind, controlled clinical trial comparing epidural butorphanol plus corticosteroid with corticosteroid alone for sciatica due to herniated nucleus pulposus. Maity, Abhijan; Mondal, Bikash Chandra; Saha, Debasish; Roy, Debasish Sinha // Perspectives in Clinical Research;2012, Vol. 3 Issue 1, p16 

    To compare the efficacy of up to 3 epidural butorphanol plus corticosteroid with corticosteroid alone for sciatica due to herniated nucleus pulposus. Materials and Methods: In a randomized, double-blind controlled clinical trial, we administered up to 3 epidural injections of either 80 mg (2 mL)...

  • Selected published abstracts of Baylor researchers.  // Baylor University Medical Center Proceedings;Apr2008, Vol. 21 Issue 2, p205 

    he article presents abstracts of research conducted by researchers at the Baylor University Medical center including bilateral infiltrating renal inflammatory pseudotumor responsive to corticosteroid therapy, improving delivery of clinical preventive services: a multi-year journey, and...

  • CORTICOSTEROIDS FOR THE TREATMENT OF CROUP. Freedman, Elizabeth S.; Jackson, Eric A. // Journal of Family Practice;Dec99, Vol. 48 Issue 12, p998 

    The article discusses research being done on the use of corticosteroids for the treatment of croup. It references a study by Ausejo et al published in a 1999 issue of the "British Medical Journal." Laryngotracheobronchitis or commonly known as croup is a common upper respiratory illness in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics