Novel epidemiological features of moyamoya disease

Baba, T; Houkin, K; Kuroda, S
August 2008
Journal of Neurology, Neurosurgery & Psychiatry;Aug2008, Vol. 79 Issue 8, p900
Academic Journal
Background: Many clinical features that are specific t~ moyamoya disease have been reported and cited in textbooks based on previous data. The purpose of this study is to investigate the present epidemiological features of moyamoya disease based on recently obtaine regional all-inclusive data. Methods: The authors performed an all-inclusive surve of moyamoya disease in Hokkaido, one of the major islands in Japan that has a population of 5.63 million. Th epidemiological features were analysed based on the dat from 267 newly registered patients with moyamoya disease in Hokkaido from 2002 to 2006. These analyse data were adjusted to the whole Japanese population a 2005. Results: The detection rate of the disease per year was 0.94 patients per 100 000 people, and prevalence was 10.5 patients per 100 000 people. The incidence of ischaemia concerned with the disease was 0.53 patients per 100 000 people-years and haemorrhage was 0.2 patients per 100 000 people-years The ratio of female to male patients was 2.18. The ratio a patients aged 10 years and above to under 10 years of age at onset was 6.18. Two peaks for age of onset wen seen: the highest was observed between 45 and 49 years, and the second between 5 and 9 years. Asymptomatic patients comprised 17.8% of the total number of patients. Conclusion: The epidemiological features of moyamoya disease determined by this survey varied considerably from previous data. The detection rate and prevalence a the disease were higher than those reported previously. The highest peak of onset age was older than those reported previously. In addition, it was revealed that asymptomatic moyamoya patients are not always rare ii Japan.


Related Articles

  • Increase in circulating CD34-positive cells in patients with angiographic evidence of moyamoya-like vessels. Yoshihara, Tomoyuki; Taguchi, Akihiko; Matsuyama, Tomohiro; Shimizu, Yoko; Kikuchi-Taura, Akie; Soma, Toshihiro; Stern, David M.; Yoshikawa, Hiroo; Kasahara, Yukiko; Moriwaki, Hiroshi; Nagatsuka, Kazuyuki; Naritomi, Hiroaki // Journal of Cerebral Blood Flow & Metabolism;Jun2008, Vol. 28 Issue 6, p1086 

    Increasing evidence points to a role for circulating endothelial progenitor cells, including populations of CD34-positive (CD34+) cells, in maintenance of cerebral blood flow. In this study, we investigated the link between the level of circulating CD34+ cells and neovascularization at ischemic...

  • Changing ischaemic lesion patterns in adult moyamoya disease. Kim, J-M.; Lee, S-H.; Roh, J-K. // Journal of Neurology, Neurosurgery & Psychiatry;Jan2009, Vol. 80 Issue 1, p36 

    Objectives: Ischaemic stroke is a frequent manifestation in patients with adult moyamoya disease (MMD), but the relationship between the lesion pattern and disease severity has rarely been investigated. Methods: Data were collected on a consecutive series of 65 adult patients with MMD who...

  • Molecular Analysis of RNF213 Gene for Moyamoya Disease in the Chinese Han Population. Zhiyuan Wu; Hanqiang Jiang; Lei Zhang; Xiao Xu; Xinju Zhang; Zhihua Kang; Donglei Song; Jin Zhang; Ming Guan; Yuxiang Gu // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    Background: Moyamoya disease (MMD) is an uncommon cerebrovascular disorder characterized by progressive occlusion of the internal carotid artery causing cerebral ischemia and hemorrhage. Genetic factors in the etiology and pathogenesis of MMD are being increasingly recognized. Previous studies...

  • Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease. Keun-Hwa Jung; Kon Chu; Soon-Tae Lee; Hee-Kwon Park; Dong-Hyun Kim; Jin-Hee Kim; Jae-Jun Bahn; Eun-Cheol Song; Manho Kim; Sang Kun Lee; Jae-Kyu Roh // Journal of Cerebral Blood Flow & Metabolism;Nov2008, Vol. 28 Issue 11, p1795 

    Moyamoya disease (MMD) is an unusual form of chronic cerebrovascular occlusive disease that involves the formation of characteristically abnormal vessels. Recent studies have reported that colony-forming unit (CFU) and outgrowth cells represent a subpopulation of endothelial progenitor cells...

  • Moyamoya disease presenting with acute subdural hemorrhage. Amit Kumar Ghosh // Neurology India;Mar/Apr2014, Vol. 62 Issue 2, p202 

    The article describes the case of a 46-year-old male patient with a history of sudden onset of loss of consciousness, headache and vomiting, and who developed Moyamoya disease, a progressive occlusion of distal internal carotid artery resulting in ischemic infarction and collateral formation....

  • ASSESSMENT OF LEG ISCHAEMIA. Nicholaides, Andrew W. // BMJ: British Medical Journal (International Edition);11/23/91, Vol. 303 Issue 6813, p1323 

    Examines the difficulties in the diagnosis of leg ischaemia with coexistent arthritis in Great Britain. Diagnostic considerations for the probable occurrence of arterial diseases in leg ischaemia; Methods of clinical examinations for ischaemia; Aspects of non-invasive tests for proper diagnosis...

  • Toe Pressure Measurements Compared to Ankle Artery Pressure Measurements. Kröger, Knut; Stewen, Christian; Santosa, Frans; Rudofsky, Gottfried // Angiology;Jan2003, Vol. 54 Issue 1, p39 

    The Trans-Atlantic Inter-Society Consensus (TASC)-recommended absolute toe pressure is < 30-50 mm Hg for definition of chronic critical limb ischemia (CLI). Toe pressures can be measured by different techniques. The authors analyzed the clinical use of the Doppler technique and an automatic...

  • The Role of SPECT and MRI for Pre and Postoperative Evaluation of Childhood Moyamoya Disease: Case Report and Review of Literature. Biswas, Shankar K.; Toyama, Hiroshi; Imizu, Shuei; Odebode, Timothy O.; Hattori, Hidekazu; Kanamori, Aya; Sarai, Magayoshi; Katada, Kazuhiro; Sano, Hirotoshi; Hishida, Hitoshi // Current Medical Imaging Reviews;2007, Vol. 3 Issue 4, p225 

    Moyamoya disease is a vascular disease of unknown aetiology characterized by chronic progressive stenosis leading to occlusion of the supraclinoid internal carotid arteries and the proximal anterior and middle cerebral arteries along with abundant collateral vessel formation. Clinically the...

  • Ivy signs on FLAIR images before and after STA-MCA anastomosis in patients with Moyamoya disease. Ideguchi, Reiko; Morikawa, Minoru; Enokizono, Mikako; Ogawa, Yoji; Nagata, Izumi; Uetani, Masataka // Acta Radiologica;Apr2011, Vol. 52 Issue 3, p291 

    Background: Leptomeningeal high signal intensity (ivy sign) on fluid-attenuated inversion-recovery (FLAIR) MR imaging is one of the features of Moyamoya disease. However, the correlation between ivy sign and cerebral perfusion status has not been fully evaluated. Purpose: To characterize ivy...


Read the Article


Sign out of this library

Other Topics