TITLE

Oxidative Stress and “Senescent” Fibroblasts in Non-Healing Wounds as Potential Therapeutic Targets

AUTHOR(S)
Clark, Richard A F
PUB. DATE
October 2008
SOURCE
Journal of Investigative Dermatology;Oct2008, Vol. 128 Issue 10, p2361
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In chronic wounds, fibroblast dysfunctions, such as increased apoptosis, premature senescence, senescence-like phenotype, or poor growth response in the absence of senescence markers, have been reported. Some of these differential dysfunctions may be secondary to differences in patient age or sex, ulcer size or duration, edge versus base sampling, or culture technique. Nevertheless, the entire spectrum of fibroblast dysfunction may exist and be secondary to, or a response to, different amounts of oxidative stress.Journal of Investigative Dermatology (2008) 128, 2361–2364. doi:10.1038/jid.2008.257
ACCESSION #
34251509

 

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