Low Proportion of Barrett's Esophagus in Asian Americans

Lam, Khoa D.; Phan, Jeanine T.; Garcia, Ruel T.; Trinh, Huy; Nguyen, Huy; Nguyen, Khanh; Triadafilopoulos, George; Vutien, Philip; Nguyen, Long; Nguyen, Mindie H.
July 2008
American Journal of Gastroenterology;Jul2008, Vol. 103 Issue 7, p1625
Academic Journal
OBJECTIVES: To determine the proportion of Barrett's esophagus (BE) in Asians versus non-Asians and the predictors of BE in patients with upper gastrointestinal (GI) symptoms. METHODS: We performed a cross-sectional study to determine the proportion of BE from all consecutive patients who underwent esophagogastroduodenoscopy (EGD) for various indications at an outpatient, community-based gastroenterology practice in northern California from February 2000 to September 2006. BE was defined as endoscopically recognized presence of salmon-pink mucosa in the distal esophagus and intestinal metaplasia on biopsy. We also performed a nested case–control study to determine potential predictors of BE. RESULTS: In total, 5,293 patients were reviewed. BE was more common in non-Asians (31/1464, 2.1%) than Asians (29/3829, 0.76%) ( P < 0.001). In multivariate analysis controlling for increasing age, male gender, ethnicity, smoking, and alcohol, the strongest predictor of the presence of BE was non-Asian ethnicity (odds ratio [OR] 3.55, 95% confidence interval [CI] 1.85–6.85), followed by male gender (OR 2.68, 95% CI 1.32–5.45). CONCLUSION: BE is uncommon in Asian Americans; non-Asian ethnicity and male gender are significant independent predictors of BE.


Related Articles

  • Response to Syed et al. Sami, Sarmed S; Ragunath, Krish; Iyer, Prasad G // American Journal of Gastroenterology;Jun2015, Vol. 110 Issue 6, p937 

    A response from the authors of the article "A Randomized Comparative Effectiveness Trial of Novel Endoscopic Techniques and Approaches for Barrett's Esophagus Screening in the Community" published in the journal in 2015 is presented.

  • Esophageal Adenocarcinoma in “Mice and Men”: Back to Basics! Attwood, Stephen E.; Harrison, Lea-Anne; Preston, Sean L.; Jankowski, Janusz A. // American Journal of Gastroenterology;Sep2008, Vol. 103 Issue 9, p2367 

    Adenocarcinoma related to Barrett's esophagus (BE) is increasing in the West faster than any other cancer. There are many potential chemopreventive agents as well as predictive biomarkers of cancer progression, but what is required is a robust high-throughput model in which to test hypotheses...

  • Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females. Derakhshan, M. H.; Liptrot, S.; Paul, J.; Brown, I. L.; Morrison, D.; McColl, K. E. L. // Gut;Jan2009, Vol. 58 Issue 1, p16 

    Background and aims: Upper gastrointestinal adenocarcinomas show an unexplained male predominance that is more apparent in oesophagus than stomach and in intestinal than diffuse histological subtype. We have conducted a population-based study to determine whether the gender phenomenon is...

  • Barrett's Esophagus and Cancer Risk: How Research Advances Can Impact Clinical Practice. di Pietro, Massimiliano; Alzoubaidi, Durayd; Fitzgerald, Rebecca C. // Gut & Liver;Jul2014, Vol. 8 Issue 4, p356 

    Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore poses a...

  • Dyspeptic Symptoms and Endoscopic Findings in the Community: The Loiano–Monghidoro Study. Zagari, Rocco Maurizio; Law, Graham Richard; Fuccio, Lorenzo; Pozzato, Paolo; Forman, David; Bazzoli, Franco // American Journal of Gastroenterology;Mar2010, Vol. 105 Issue 3, p565 

    OBJECTIVES:We aimed to evaluate the prevalence of endoscopic findings and their association with dyspeptic symptoms in the community.METHODS:A total of 1,533 inhabitants of two villages were invited to participate in a cross-sectional survey, and 1,033 were recruited. Participants underwent a...

  • Prague C&M and Japanese criteria: shades of Barrett's esophagus endoscopic diagnosis. Kinjo, Tetsu; Kusano, Chika; Oda, Ichiro; Gotoda, Takuji // Journal of Gastroenterology;Oct2010, Vol. 45 Issue 10, p1039 

    Background: The anatomical reference points used to endoscopically diagnose Barrett's esophagus (BE) differ between Japan and other countries. The esophageal gastric junction (EGJ) is defined as the distal limit of the lower esophageal longitudinal or palisade vessels in Japan, but as the...

  • British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus. Fitzgerald, Rebecca C.; di Pietro, Massimiliano; Ragunath, Krish; Yeng Ang; Jin-Yong Kang; Watson, Peter; Trudgill, Nigel; Patel, Praful; Kaye, Philip V.; Sanders, Scott; O'Donovan, Maria; Bird-Lieberman, Elizabeth; Bhandari, Pradeep; Jankowski, Janusz A.; Attwood, Stephen; Parsons, Simon L.; Loft, Duncan; Lagergren, Jesper; Moayyedi, Paul; Lyratzopoulos, Georgios // Gut;Jan2014, Vol. 63 Issue 1, p7 

    These guidelines provide a practical and evidence-based resource for the management of patients with Barrett's oesophagus and related early neoplasia. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was followed to provide a methodological strategy for the guideline...

  • Improved Detection of Incident Dysplasia by Probe-Based Confocal Laser Endomicroscopy in a Barrett's Esophagus Surveillance Program. Bertani, Helga; Frazzoni, Marzio; Dabizzi, Emanuele; Pigò, Flavia; Losi, Luisa; Manno, Mauro; Manta, Raffaele; Bassotti, Gabrio; Conigliaro, Rita // Digestive Diseases & Sciences;Jan2013, Vol. 58 Issue 1, p188 

    Background: Probe-based confocal laser endomicroscopy (pCLE) is a new technique allowing in vivo detection of neoplastic tissue using a standard endoscope. Aims: Our aim was to compare the incident dysplasia detection rate of biopsies obtained by high-definition white light endoscopy (HD-WLE) or...

  • Diagnosis and treatment of Barrett's oesophagus. Lim, Yean Cheant; Fitzgerald, Rebecca C. // British Medical Bulletin;Sep2013, Vol. 107 Issue 1, p117 

    Introduction Barrett's oesophagus (BO) is a common premalignant condition, which carries a risk of progression to oesophageal adenocarcinoma. Recent advances include quantifying the risk of neoplasia progression, novel diagnostic tools and development of new endoscopic techniques to treat early...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics