Development of saw palmetto ( Serenoa repens) fruit and extract standard reference materials

Schantz, Michele M.; Bedner, Mary; Long, Stephen E.; Molloy, John L.; Murphy, Karen E.; Porter, Barbara J.; Putzbach, Karsten; Rimmer, Catherine A.; Sander, Lane C.; Sharpless, Katherine E.; Thomas, Jeanice B.; Wise, Stephen A.; Wood, Laura J.; Yen, James H.; Yarita, Takashi; NguyenPho, Agnes; Sorenson, Wendy R.; Betz, Joseph M.
October 2008
Analytical & Bioanalytical Chemistry;Oct2008, Vol. 392 Issue 3, p427
Academic Journal
As part of a collaboration with the National Institutes of Health’s Office of Dietary Supplements and the Food and Drug Administration’s Center for Drug Evaluation and Research, the National Institute of Standards and Technology has developed two standard reference materials (SRMs) representing different forms of saw palmetto ( Serenoa repens), SRM 3250 Serenoa repens fruit and SRM 3251 Serenoa repens extract. Both of these SRMs have been characterized for their fatty acid and phytosterol content. The fatty acid concentration values are based on results from gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC/MS) analysis while the sterol concentration values are based on results from GC-FID and liquid chromatography with mass spectrometry analysis. In addition, SRM 3250 has been characterized for lead content, and SRM 3251 has been characterized for the content of β-carotene and tocopherols. SRM 3250 (fruit) has certified concentration values for three phytosterols, 14 fatty acids as triglycerides, and lead along with reference concentration values for four fatty acids as triglycerides and 16 free fatty acids. SRM 3251 (extract) has certified concentration values for three phytosterols, 17 fatty acids as triglycerides, β-carotene, and γ-tocopherol along with reference concentration values for three fatty acids as triglycerides, 17 fatty acids as free fatty acids, β-carotene isomers, and δ-tocopherol and information values for two phytosterols. These SRMs will complement other reference materials currently available with concentrations for similar analytes and are part of a series of SRMs being developed for dietary supplements.


Related Articles

  • saw palmetto.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2072 

    An encyclopedia entry for "saw palmetto," is presented, which refers to a low-growing palm whose extract is used to treat benign prostatic hyperplasia.

  • Growth of Serenoa repens Planted in a Former Agricultural Site. Foster, Tammy E.; Schmalzer, Paul A. // Southeastern Naturalist;2012, Vol. 11 Issue 2, p331 

    Serenoa repens (Saw Palmetto) is an important plant in many Florida habitats; not only does it provide food and shelter for numerous species, but it is also a highly flammable species that is fuel for fire in many of Florida's fire-maintained ecosystems. With loss of natural area due to...

  • Prostate & Urinary.  // Life Extension;May2003 Supplement, Vol. 9, p206 

    Assesses the alleviation of benign prostate enlargement by plant extracts. Suppression of a testosterone metabolite by prescription drug Proscar; Reduction of enlarged prostate glands by Natural Prostate Formula therapy; Inhibition of the 5-alpha reductase enzyme in the gland by saw-palmetto.

  • dear reader. Blumenthal, Mark // HerbalGram;Winter2005, Issue 65, p5 

    Focuses on the continuing downfall of the saw palmetto market in the U.S. Factors contributing to the negative condition of the industry; Nature of saw palmetto; Medicinal use of saw palmetto oil.

  • saw palmetto.  // Taber's Cyclopedic Medical Dictionary;2005, p1945 

    A definition of the term "saw palmetto" is presented. It refers to a low-growing, spreading palm Serenoa repens native to Florida and the coastal southeastern U.S. Its extract is promoted as a treatment for benign prostatic hyperplasia.

  • dear reader. Blumenthal, Mark // HerbalGram;Fall2004, Issue 64, p5 

    Comments on the effects of weather patterns and political events on the availability and pricing of medicinal plant and spice crops, specifically saw palmetto. Devastation of saw palmetto in Florida; Possibility of adulteration of oil from saw palmetto with lower cost ingredients by some...

  • Saw palmetto effective for BPH in European study. Harrison, Laird // Urology Times;Sep2004, Vol. 32 Issue 13, p6 

    Reveals the finding from a study that phytotherapy with the saw palmetto extract Serenoa repens appears to be more effective than an alpha-blocker in relieving severe benign prostatic hyperplasia. Number of patients examined for the study; Factors measured in these patients; Discovery of slight...

  • Serenoa repens for Benign Prostatic Hyperplasia. Underland, Vigdis; Sæterdal, Ingvil; Nilsen, Elin Strømme // Alternative Therapies in Health & Medicine;Jan/Feb2011, Vol. 17 Issue 1, p8 

    The article presents a summary of the findings of several studies which examine the effect of Serenoa repens for benign prostatic hyperplasia (BPH) vs placebo. It notes that serenoa repens is a plant extract which is widely used as an alternative therapy to BPH, along with the prescribed...

  • Saw palmetto extracts for benign prostatic hyperplasia. Segars, Larry W. // Journal of Family Practice;Feb1999, Vol. 48 Issue 2, p88 

    The article examines whether saw palmetto extracts are effective for the treatment of benign prostatic hypertrophy (BPH). Symptoms associated with BPH are common in elderly men and can include urgency, frequency, hesitancy, weak stream, and incomplete voiding. The authors review available data...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics