The Effect of Clove Bud, Nigella and Salix Alba on Wart and Comparison with Conventional Therapy

Rezaei, Kobra; Jebraeili, Roghieh; Delfan, Bahram; Noorytajer, Maryam; Meshkat, Mohammad Hadi; Maturianpour, Hossein
August 2008
European Journal of Scientific Research;Aug2008, Vol. 21 Issue 3, p444
Academic Journal
Backgrounds: Wart is a common viral disease of the skin due to papilloma virus infection. Its prevalence among children and young adults is about 10% which 70% of them are common wart. Salicylic acid 16.7% and lactic acid 16.7% are the most conventional therapy for wart. The plants Clove bud, Olive, Nigel and Salix alba have wound disinfectant, anesthesia, analgesia and wound healing properties. The aim of this study was to investigate the effect of Clove bud, Nigella, Salix alba and Olive oil on wart treatment in comparison with conventional treatment. Method: This randomized double blind controlled clinical trial was conducted on 291 female students which were selected form guidance schools and high schools in Khoram Abad, Lorestan, Iran, during the year 2007. The diagnosis of wart was confirmed by a dermatologist according to the diagnosis criteria. The cases fulfilling the inclusion criteria were assigned in each 3 study groups randomly (97 cases in each group). The cases were categorized in 3 groups. The first group was treated with conventional treatment (Salicylic acid 16.7%, lactic acid 16.7% in collodione body), the second group with herbal medicine without acid in olive oil, and the third group with herbal medicine alongside salicylic acid 1% and lactic acid 1% in olive oil. Each group was administered the drugs for 6 weeks. The effect of drugs on lesions was assessed after 4 and 6 weeks and compared between 3 groups using repeated measures test. Results: The age range of cases was 12-18 years. 64.41% lesions were located on hands, the rest presenting on other regions. Of 291 cases a total of 177 cases used the drug on a regular basis. Improvement of lesion after 4 weeks was 62.6% for conventional therapy, 42.9% far herbal therapy with acid, and 55.1% for herbal therapy without acid as well as 89.9% for conventional therapy, 61.3% for herbal therapy with acid, and 87.8% for herbal therapy without acid after 6 weeks. Routine treatment was more efficient than herbal therapy with acid (P<0.000). The efficacy of routine therapy was not significantly different from that of herbal therapy without acid (P = 1.000) and herbal therapy with acid was less efficient than herbal therapy without acid (P < 0.001). Conclusion: The use of herbal therapy, with or without acid is significantly efficient in lesion resolution. Also, a prolonged duration of therapy leads to better resolution of lesions in all three types of therapy. With regard to these results, the mentioned plants may be used as adjuvant or alternative therapy in treatment of common wart.


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