TITLE

Esophageal Adenocarcinoma in “Mice and Men”: Back to Basics!

AUTHOR(S)
Attwood, Stephen E.; Harrison, Lea-Anne; Preston, Sean L.; Jankowski, Janusz A.
PUB. DATE
September 2008
SOURCE
American Journal of Gastroenterology;Sep2008, Vol. 103 Issue 9, p2367
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Adenocarcinoma related to Barrett's esophagus (BE) is increasing in the West faster than any other cancer. There are many potential chemopreventive agents as well as predictive biomarkers of cancer progression, but what is required is a robust high-throughput model in which to test hypotheses preclinically. The pathophysiology of metaplasia and cancer has been studied in 10 animal species. Though they have considerable genetic divergence, anatomical dissimilarity, and experimental flaws, they have provided some data to test in the clinic, especially relating to activation of common genetic pathways, role of hypergastrinemia, and duodenogastric reflux in cancer progression. In this regard, the human postesophagectomy model, which has a 30% recurrence of BE within 3 yr and a 5% recurrence of adenocarcinoma over 10 yr, is now being utilized to understand how human metaplasia occurs. Furthermore, improved clinical trial designs mean that more sophisticated questions can be addressed in man.
ACCESSION #
34050179

 

Related Articles

  • Oesophageal and gastric intestinal-type adenocarcinomas show the same male predominance due to a 17 year delayed development in females. Derakhshan, M. H.; Liptrot, S.; Paul, J.; Brown, I. L.; Morrison, D.; McColl, K. E. L. // Gut;Jan2009, Vol. 58 Issue 1, p16 

    Background and aims: Upper gastrointestinal adenocarcinomas show an unexplained male predominance that is more apparent in oesophagus than stomach and in intestinal than diffuse histological subtype. We have conducted a population-based study to determine whether the gender phenomenon is...

  • Low Proportion of Barrett's Esophagus in Asian Americans. Lam, Khoa D.; Phan, Jeanine T.; Garcia, Ruel T.; Trinh, Huy; Nguyen, Huy; Nguyen, Khanh; Triadafilopoulos, George; Vutien, Philip; Nguyen, Long; Nguyen, Mindie H. // American Journal of Gastroenterology;Jul2008, Vol. 103 Issue 7, p1625 

    OBJECTIVES: To determine the proportion of Barrett's esophagus (BE) in Asians versus non-Asians and the predictors of BE in patients with upper gastrointestinal (GI) symptoms. METHODS: We performed a cross-sectional study to determine the proportion of BE from all consecutive patients who...

  • Diagnosis and grading of dysplasia in Barrett’s oesophagus. R D Odze // Journal of Clinical Pathology;Oct2006, Vol. 59 Issue 10, p1029 

    This review focuses on the pathological features of dysplasia in Barrett’s oesophagus. Two categorisation schemes are used for grading dysplasia in the gastrointestinal tract, including Barrett’s oesophagus. The inflammatory bowel disease dysplasia morphology study group system is...

  • Barrett's Esophagus and Cancer Risk: How Research Advances Can Impact Clinical Practice. di Pietro, Massimiliano; Alzoubaidi, Durayd; Fitzgerald, Rebecca C. // Gut & Liver;Jul2014, Vol. 8 Issue 4, p356 

    Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore poses a...

  • Elevated Serum Gastrin Is Associated With a History of Advanced Neoplasia in Barrett's Esophagus. Wang, Judy S; Varro, Andrea; Lightdale, Charles J; Lertkowit, Nantaporn; Slack, Kristen N; Fingerhood, Michael L; Tsai, Wei Yann; Wang, Timothy C; Abrams, Julian A // American Journal of Gastroenterology;May2010, Vol. 105 Issue 5, p1039 

    OBJECTIVES:Proton pump inhibitors (PPIs) are frequently prescribed to patients with Barrett's esophagus (BE), but in a subset, they can induce significant hypergastrinemia. Elevated levels of gastrin have been associated with tumorigenic effects in a number of gastrointestinal cancers. We...

  • Diagnosis and treatment of Barrett's oesophagus. Lim, Yean Cheant; Fitzgerald, Rebecca C. // British Medical Bulletin;Sep2013, Vol. 107 Issue 1, p117 

    Introduction Barrett's oesophagus (BO) is a common premalignant condition, which carries a risk of progression to oesophageal adenocarcinoma. Recent advances include quantifying the risk of neoplasia progression, novel diagnostic tools and development of new endoscopic techniques to treat early...

  • Barrett's Adenocarcinoma of the Esophagus. Behrens, Angelika; Pech, Oliver; Graupe, Florian; May, Andrea; Lorenz, Dietmar; Ell, Christian // Deutsches Aerzteblatt International;5/6/2011, Vol. 108 Issue 18, following p319 

    A bibliography on the subject of new methods of diagnosis and treatment is presented which includes articles "Acid has antiproliferative effects in nonoplastic Barrett's epithelial cells,' by Feagins L. A. and colleagues, "Selective inhibition of cyclooxygenase 2 suppresses growth and induces...

  • Neoadjuvant Conformal Chemoradiation with Induction Chemotherapy for Rectal Adenocarcinoma. A Prospective Observational Study. Fekete, Zsolt; Muntean, Alina-Simona; Hica, Ştefan; Rancea, Alin; Resiga, Liliana; Csutak, Csaba; Todor, Nicolae; Nagy, Viorica Magdalena // Journal of Gastrointestinal & Liver Diseases;Jun2014, Vol. 23 Issue 2, p171 

    Background & Aims: The purpose of this prospective observational study was to evaluate the rate and the prognostic factors for down-staging and complete response for rectal adenocarcinoma after induction chemotherapy and neoadjuvant chemoradiation followed by surgery, and to analyze the rate of...

  • Significance of Persistent Nondysplasia Over Multiple Endoscopic Surveillance in Risk Stratification of Patients With Barrett's Esophagus. Jeong Hwan Kim // Journal of Neurogastroenterology & Motility;Oct2013, Vol. 19 Issue 4, p542 

    In this article, the author comments on the research "Persistence of nondysplastic Barrett's esophagus identifies patients at lower risk for esophageal adenocarcinoma: Results from a large multicenter cohort" by S. Gaddam and colleagues, published in the journal "Gastroenterology" in the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics