TITLE

Effects of angiotensin converting enzyme inhibition on cardiac innervation and ventricular arrhythmias after myocardial infarction

AUTHOR(S)
Su-Hua Yan; He-Sheng Hu; Le-Xin Wang; Qi-Chong Xing; Wen-Juan Cheng; Mei Xue
PUB. DATE
August 2008
SOURCE
Clinical & Investigative Medicine;Aug2008, Vol. 31 Issue 4, pE198
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: To investigate the influence of angiotensinconverting enzyme inhibitor (ACEI) on cardiac innervation and inducible ventricular arrhythmias (VAs) in healed myocardial infarction (MI). Methods: Left anterior descending coronary artery was ligated to induce MI in 30 rabbits. After oral captopril (10mg/kg/d) for 8 weeks, electrophysiological study was performed to evaluate the incidence of inducible VAs. RTPCR and immunohistochemistry were used to measure the cardiac innervation. Results: Eight weeks after the operation, the incidence of inducible VAs in the MI-placebo group was higher (58.3%, 7/12) than in the sham operation group (16.7%, 2/12, P<0.05). However, the incidence of inducible VAs in the MIcaptopril group was lower (27.2%, 3/11) than in the MIplacebo group (P<0.05). Proliferation and growth of nerve fibres in the MI-placebo group were mainly distributed at the periphery of the infarcted and perivascular regions of the myocardium. The density of nerve fibres increased in the MI-placebo group (3889±521 μm²/mm²) compared with the sham group (1727±304 μm²/mm², P<0.01) at the infarct border. In the MI-captopril group, the density of nerve fibres (3507±433 μm
ACCESSION #
34039010

 

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