Transcutaneous Electrogastrography in Patients with Ileus

Fraško, R.; Maruna, P.; Gürlich, R.; Trca, S.
August 2008
European Surgical Research;2008, Vol. 41 Issue 2, p197
Academic Journal
Background: The aim of the prospective study was to characterize the disturbance of gastric electrical control activity in different types of ileus and to correlate surface electrogastrography (EGG) findings with a set of inflammatory markers. Patients and Methods: Fifty-four adult patients with mechanic, vascular and paralytic ileus proven on clinical and radiological exams and 14 age- and sex-matched controls were examined. Gastric myoelectrical activity was recorded using 3 Ag-AgCl disposable skin electrodes connected in pseudo-unipolar mode by Microdigitrapper device. The captured signal was amplified and digitalized. The dominant frequency was calculated using computerized algorithms (Fast Fourier transform and running spectrum analysis). The results were correlated with the known pathological diagnoses and 4 inflammatory parameters – interleukin (IL)-1β, IL-6, procalcitonin (PCT) and C-reactive protein. Results: Irregular EGG activity without a dominant frequency or bradygastria (electrical control activity frequency <2.4 cycles/min) was seen in all patients with both vascular and parayltic ileus and in 67.86% of the patients with obstructive ileus. Normogastria (2.4–3.7 cycles/min) was found in 32.14% of the patients with obstructive ileus. Among the patients with obstructive ileus and bradygastria, higher concentrations of IL-6 (642.0 ± 214.7 ng/l) and PCT (0.93 ± 0.22 μg/l) were observed compared with the patients with normogastria – IL-6 (354.5 ± 109.2 ng/l), PCT (0.69 ± 0.11 μg/l); p < 0.05 for both. The C-reactive protein concentration did not differ in both subgroups on p < 0.05. Conclusions: EGG examination confirmed a high sensitivity in the evaluation of gastric electrical control activity in both vascular and paralytic ileus. Significant correlation of EGG findings and both IL-6 and PCT plasma levels supports a role of the inflammatory milieu in the pathogenesis of impaired gastric electrical activity in patients with ileus. Copyright © 2008 S. Karger AG, Basel


Related Articles

  • Update on chronic intestinal pseudo-obstruction. Scalera, Irene; Giannini, Ivana; Franco, Isabella; Guglielmi, Altomarino; Rinaldi, Marcella; Altomare, Donato F. // Nutritional Therapy & Metabolism;Jan-Mar2011, Vol. 29 Issue 1, p1 

    Recent insights into the etiopathology, diagnosis, classification, and therapy of chronic intestinal pseudo-obstruction are reviewed in this study. Four cases observed and treated in our institution with simultaneous implant of gastric and sacral neurostimulation are also described.

  • Interleukin-6 and C-reactive protein as early markers of sepsis in patients with diabetic ketoacidosis or hyperosmosis. Gogos, C. A.; Giali, S.; Paliogianni, F.; Dimitracopoulos, G.; Bassaris, H. P.; Vagenakis, A. G. // Diabetologia;Aug2001, Vol. 44 Issue 8, p1011 

    Aims/hypothesis: An early diagnosis of sepsis in patients with diabetic ketoacidosis and hyperosmolar non-ketotic coma is crucial and could save lives. We studied serum C-reactive protein and interleukin-6 to find out how useful these might be for identifying sepsis. Methods: Sixty one diabetic...

  • Rheumatoid arthritis and diabetes. MacLennan, W. J. // Age & Ageing;Sep2007, Vol. 36 Issue 5, p486 

    The article reports on a review conducted among 5,302 subjects regarding the relation between rheumatoid arthritis and diabetes mellitus. It says that both conditions are characterized by high levels of C-reactive protein (CRP) and interleukin-6 (Il-6) but there was no association. It mentions...

  • Disturbances of Gastric Electrical Control Activity after Laparotomic Cholecystectomy Are Related to Interleukin-6 Concentrations. Maruna, P.; Frasko, R.; Lindner, J. // European Surgical Research;2009, Vol. 43 Issue 4, p317 

    Background: The aim of the present study was to characterize the disturbances of gastric electrical control activity after cholecystectomy and to correlate electrogastrographic (EGG) findings with inflammatory markers. Patients and Methods: 52 adult patients were examined in conjunction with...

  • Comparison of serum IL-1β, sIL-2R, IL-6, and TNF-α levels with disease activity parameters in ankylosing spondylitis. Bal, A.; Unlu, E.; Bahar, G.; Aydog, E.; Eksioglu, E.; Yorgancioglu, R. // Clinical Rheumatology;Feb2007, Vol. 26 Issue 2, p211 

    Ankylosing spondylitis (AS) is a chronic, inflammatory, rheumatological disease affecting primarily the sacroiliac joint and vertebral column, with an etiology that remains obscure. Cytokines are soluble proteins that have specific roles in inflammatory response, arranging the interaction...

  • Effects of trimebutine maleate on gastric motility in patients with gastric ulcer. Kamiya, Takeshi; Nagao, Toshihiro; Andou, Takashi; Misu, Naoko; Kobayashi, Yuka; Hirako, Makoto; Hara, Michiko; Fujinami, Takao; Kamiya, T; Nagao, T; Andou, T; Misu, N; Kobayashi, Y; Hirako, M; Hara, M; Fujinami, T // Journal of Gastroenterology;1998, Vol. 33 Issue 6, p823 

    The effects of trimebutine maleate (TM), a prokinetic drug, on gastrointestinal motility in patients with gastric ulcer were investigated. Twenty patients with active gastric ulcers were allocated to two groups; 10 patients received a proton pump inhibitor alone (PPI group), given orally, and 10...

  • New strategies in sepsis diagnosis. Pieteris, Linas; Bakšytė, Giedrė; Česnaitis, Tadas; Vitkauskienė, Astra; Macas, Andrius // Acta Medica Lituanica;2012, Vol. 19 Issue 3, p160 

    Successful treatment of sepsis begins from early diagnosis and prognosis. In last decades the number of sepsis cases is growing, so establishing early diagnosis of sepsis as well as effectiveness of treatment are very significant. That is why development of new diagnostic sepsis markers is...

  • Interleukin-6 (IL-6) and soluble receptors for interleukin-2 (sIL-2R) in the diagnosis of early severe infection in the critically ill newborns. Matić, Marjeta Tomšič; Derganc, Metka; Wraber, Branka; Janey Primožič // Pflugers Archiv European Journal of Physiology;Sep2000 Supplement, Vol. 440, pR75 

    The aim of our study was to evaluate the diagnostic accuracy of serial determination of interleukin-6 (IL-6) and soluble receptors of interleukin-2 (sIL-2R) in the diagnosis of early infection in the critically ill newborns and compare it with the routinely used C-reactive protein (CRP)....

  • Rapid diagnosis of sepsis. Bloos, Frank; Reinhart, Konrad // Virulence;Jan2014, Vol. 5 Issue 1, p219 

    Fast and appropriate therapy is the cornerstone in the therapy of sepsis. However, the discrimination of sepsis from non-infectious causes of inflammation may be difficult. Biomarkers have been suggested to aid physicians in this decision. There is currently no biochemical technique available...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics