Peripheral Arterial Disease: Diagnosis and Management

Arain, Faisal A.; Cooper Jr., Leslie T.
August 2008
Mayo Clinic Proceedings;Aug2008, Vol. 83 Issue 8, p944
Academic Journal
Peripheral arterial disease is a common but underdiagnosed and undertreated disorder with substantial morbidity and mortality. The pathophysiology of peripheral arterial disease and the risk factors for developing it are similar to those for atherosclerotic disease occurring at other sites. Peripheral arterial disease can be diagnosed accurately with simple, noninvasive, office-based tests that measure the severity of the disease and provide valuable prognostic Information. Optimal medical therapy includes a supervised exercise program, tobacco cessation, and modification of treatable risk factors. Cilostazol can improve pain-free and peak walking distances in patients with intermittent claudication. As a general rule, patients with lifestyle-limiting claudication who do not respond to medical management or those with critical limb ischemia should be referred to a vascular specialist for consideration of revascularizatlon.


Related Articles

  • Ischemic stroke in patients with intermittent claudication: a clinical study of 142 cases. Arboix, Adrià; Tarruella, Marc; García-Eroles, Lluis; Oliveres, Montserrat; Miquel, Caries; Balcells, Miquel; Targa, Cecilia // Vascular Medicine;2004, Vol. 9 Issue 1, p13 

    The clinical features, risk factors, neuroimaging findings, and outcome of acute ischemic stroke were assessed in patients with intermittent claudication. Data from 142 patients with ischemic stroke and intermittent claudication were collected from a prospective hospital-based stroke registry in...

  • Relative Importance of Various Risk Factors for Asymptomatic Carotid Atherosclerosis versus Coronary Heart Disease Incidence: The Atherosclerosis Risk In Communities Study. Sharrett, A. R.; Sorlie, P. D.; Chambless, L E.; Folsom, A. R.; Hutchinson, R. G.; Heiss, G.; Szklo, M. // American Journal of Epidemiology;1999, Vol. 149 Issue 9, p843 

    Major risk factors for coronary heart disease are also associated with early carotid artery thickening, but no studies have yet examined patterns of risk factors to see whether they differ for the two outcomes. Assuming similar pathogenesis for both coronary and carotid atherosclerosis, one...

  • Functional status measured by walking impairment questionnaire and cardiovascular risk prediction in peripheral arterial disease: results of the Peripheral Arteriopathy and Cardiovascular Events (PACE) study. Schiano, Vittorio; Brevetti, Gregorio; Sirico, Giusy; Silvestro, Antonio; Giugliano, Giuseppe; Chiariello, Massimo // Vascular Medicine;2006, Vol. 11 Issue 3, p147 

    The prognostic impact of the functional status of patients with intermittent claudication is still obscure. From the lists of seven general practitioners, we identified all subjects aged 40–80 years (n = 4352). Of those reporting leg symptoms while walking on the Rose questionnaire (n =...

  • A Case of Popliteal Artery Entrapment Syndrome Presenting with Acute Limb Ischaemia. Jo, Byeong-joo; Bae, Jun-Ho // Heart, Lung & Circulation;Dec2014, Vol. 23 Issue 12, pe255 

    Popliteal artery entrapment syndrome (PAES) is caused by an anomalous anatomic relationship between the popliteal artery and the musculotendinous structures in the popliteal fossa. In the early stage of PAES, patients most commonly present with intermittent claudication. If we don’t...

  • Vascular Disease Patient Information Page: Peripheral artery disease. Ratchford, Elizabeth V; Evans, Natalie S // Vascular Medicine;Jun2014, Vol. 19 Issue 3, p218 

    The article presents the information page for patients with vascular diseases. It provides an overview on the definition of peripheral artery disease (PAD) and its risk for peropheral artery disease. It also mentions the signs and symptoms of PAD which is commonly affecting between 8 and 12...

  • Risk for Cardiovascular Disease in Pregnant Women with Familial Hypercholesterolemiaz A Review on the Endothelial and Hemostatic Balance in a Clinical Perspective. Rettersel, Kjettil; Toleikyte, leva; lversen, Ole // Journal of Coagulation Disorders;Oct2011, Vol. 3 Issue 1, p49 

    OBJECTIVES Familial hypercholesterolemia leads to a markedly increased risk for atherosclerotic disease with a more pronounced increase in relative risk in young middle aged patients versus older. Women with FH need to stop treatment with virtually all types of lipid lowering medication during...

  • Prevalence and risk factors associated with peripheral artery disease in elderly patients undergoing peritoneal dialysis. Ding-Wei Kuang; Chiu-Leong Li; Un-I Kuok; Kin Cheung; Weng-In Lio; Jing Xin // Vascular Health & Risk Management;2012 Part 2, Vol. 8, p581 

    Background: Rapid growth of the elderly peritoneal dialysis (PD) population is posing a special challenge for renal teams. Peripheral artery disease (PAD) has been reported to be an independent predictor of cardiovascular and all-cause mortality in hemodialysis patients. However, the prevalence...

  • Physical activity in the prevention of peripheral artery disease in the elderly. Schiattarella, Gabriele G.; Perrino, Cinzia; Magliulo, Fabio; Carbone, Andreina; Bruno, Antonio G.; Paulis, Michele De; Sorropago, Antonio; Corrado, Roberto V.; Bottino, Roberta; Menafra, Giovanni; Abete, Raffaele; Toscano, Evelina; Giugliano, Giuseppe; Trimarco, Bruno; Esposito, Giovanni // Frontiers in Physiology;Mar2014, Vol. 5, p1 

    Aging is a well-known cardiovascular risk factor and cardiovascular diseases (CVD) are estimated to be the most common cause of death in the elderly. Peripheral arterial disease (PAD) represents an important clinical manifestation of CVD leading to increase morbidity and mortality, especially in...

  • Retroperitoneal fibrosis. Tzou, Martha; Gazeley, David J; Mason, Peter J // Vascular Medicine;Oct2014, Vol. 19 Issue 5, p407 

    Retroperitoneal fibrosis (RPF) is a rare disease that is marked by systemic inflammation and the development of a periaortic fibroinflammatory mass. The fibroinflammatory infiltration can encase the abdominal aorta, ureters, and other abdominal organs. The clinical presentation often includes...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics