TITLE

A Practical "ABCDE" Approach to the Metabolic Syndrome

AUTHOR(S)
Blaha, Michael J.; Bansae, Sandeep; Rouf, Rosanne; Golden, Sherita H.; Blumenthal, Roger S.; DeFlippis, Andrew P.
PUB. DATE
August 2008
SOURCE
Mayo Clinic Proceedings;Aug2008, Vol. 83 Issue 8, p932
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The metabolic syndrome comprises a cluster of risk factors for cardiovascular disease and type 2 dIabetes mellltus that are due to abdominal obesity and insulin resistance. This increasingly important proinflammatory condition remains both underrecognized and undertreated. To aid physicians In their approach to the metabolic syndrome, we assessed and synthesized the literature on cardiovascular risk assessment and early Intervention for risk reduction. We performed a comprehensive search of MEDLINE and the Cochrane database for peer-reviewed clinical studies published from January 1, 1988, to December 31, 2007, augmented by consultation with content experts. We used the search terms metabolic syndrome, abdominal obesity, waist circumference, insulin resistance, cardiovascular disease, prediabetes, diabetes, treatment, prevention, aspirin, hypertension, cholesterol, atherogenic dyslipidemia, lifestyle therapy, diet, and exercise. Criteria used for study review were controlled study design, English language, relevance to clinicians, and validity based on experimental design and appropriateness of conclusions. Although growing evidence supports early Intervention in patients with the metabolic syndrome, many physicians do not recognize the risk assocIated with this condition and fall to initiate early treatment. A comprehensive management plan can be assembled through an "ABCDE" approach: "A" for assessment of cardiovascular risk and aspirin therapy, "B" for blood pressure control, "C" for cholesterol manage- ment, `ID" for diabetes prevention and diet therapy, and "E" for exercise therapy. This ABCDE approach provides a practical and systematic framework for encouraging metabolic syndrome recognition and for Implementing a comprehensive, evidence-based management plan for the reduction of cardiovascular risk.
ACCESSION #
33967217

 

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