Safety of Prescribing PDE-5 Inhibitors via e-Medicine vs Traditional Medicine

Munger, Mark A.; Stoddard, Gregory J.; Wenner, Allen R.; Bachman, John W.; Jurige, John H.; Poe, Laura; Baker, Diana L.
August 2008
Mayo Clinic Proceedings;Aug2008, Vol. 83 Issue 8, p890
Academic Journal
OBJECTIVE: To determine the safety of a US-based, state-regulated Internet system vs a multispecialty primary care system for prescribing phosphodiesterase type 5 (PDE-5) inhibitors for erectile dysfunction. PATIENTS AND METHODS: From January 1, 2001, through December 31, 2005, 500 e-medlcine clients (mean ± SD age, 47±11 years; hypertension, 60%; type 2 diabetes meilitus, 2%; mean ± SD number of medications, 0.4±0.8) vs 500 traditional medicine patients (mean ± SD age, 57±12 years; hypertension, 50%; type 2 diabetes mellitus, 23%; mean ± SD number of medications, 5.1±3.1) with erectile dysfunction symptoms were assessed. Noninferiority safety was assessed in this retrospective, crosssectional study with stratified random sampling by identification of prescribing in the presence of clinically important PDE-5 inhibitor drug interactions with or without high-risk cardiovascular disease, by asking about diagnostic symptoms specific to erectile dysfunction, and by determining frequency of patient counseling. RESULTS: Noninferiority of the e-medicine system was shown for the 6 safety end points, relative to a traditional medicine system. Numbers of inappropriate prescriptions, after correction for disease and medication covariates, did not differ between systems. Medication éounseling showed superiority of the e-medicine system. Standard diagnostic questions were required for e-mediclne prescribing but were infrequently asked in traditional medicine. CONCLUSION: Safety in prescribing PDE-5 inhibitors for erectile dysfunction was similar between a US-based, state-regulated Internet prescribing system and a multispecialty primary care system.


Related Articles

  • Individual-based primary prevention of cardiovascular disease in Cambodia and Mongolia: early identification and management of hypertension and diabetes mellitus. Otgontuya, Dugee; Oum, Sophal; Palam, Enkhtuya; Rani, Manju; Buckley, Brian S. // BMC Public Health;2012, Vol. 12 Issue 1, p254 

    Background: To assess the coverage of individual-based primary prevention strategies for cardiovascular disease (CVD) in Cambodia and Mongolia: specifically the early identification of hypertension and diabetes mellitus, major proximate physiological CVD risk factors, and management with...

  • PHOs get checked for diabetes action. Tatham, Helen // New Zealand Doctor;10/19/2011, p4 

    The article reports on the launch of a review of New Zealand government's national diabetes and cardiovascular disease target which will be linked with the Primary Health Organisation (PHO) Performance Programme following an assessment that the Diabetes Get Checked programme lacked impact.

  • Autoimmune disease CVD risk. Baines, Emma // GP: General Practitioner;2/2/2004, p21 

    General practitioners (GPs) should do more to reduce cardiovascular disease (CVD) risk factors in patients with systemic lupus erythematosus (SLE) because they are at increased risk of coronary events, according to a review study. It found that patients with SLE have up to 10 times the risk of...

  • Utilization of Primary and Obstetric Care After Medically Complicated Pregnancies: An Analysis of Medical Claims Data. Bennett, Wendy; Chang, Hsien-Yen; Levine, David; Wang, Lin; Neale, Donna; Werner, Erika; Clark, Jeanne // JGIM: Journal of General Internal Medicine;Apr2014, Vol. 29 Issue 4, p636 

    BACKGROUND: Because pregnancy complications, including gestational diabetes mellitus (GDM) and hypertensive disorders in pregnancy, are risk factors for diabetes and cardiovascular disease, post-delivery follow-up is recommended. OBJECTIVE: To determine predictors of post-delivery primary and...

  • DEPRESSION IN PRIMARY CARE. Elliott, Richard L. // Ethnicity & Disease;Spring2007, Vol. 17 Issue 2, p28 

    The article discusses approaches to the diagnosis and treatment of depression among primary care patients. Depression increases the risk of cardiovascular disease, diabetes, hypertension, stroke, medically unexplained symptoms, chronic pain, anxiety disorders and substance abuse. Diagnosis and...

  • Implementation of clinical guidelines on diabetes and hypertension in urban Mongolia: a qualitative study of primary care providers' perspectives and experiences. Chimeddamba, Oyun; Peeters, Anna; Ayton, Darshini; Tumenjargal, Enkhjargal; Sodov, Sonin; Joyce, Catherine // Implementation Science;Aug2015, Vol. 10 Issue 1, p1 

    Background: Hypertension and diabetes, key risk factors for cardiovascular disease, are significant health problems globally. As cardiovascular disease is one of the leading causes of mortality in Mongolia since 2000, clinical guidelines on arterial hypertension and diabetes were...

  • 'Significant' link found between ED, heart disease. Nierengarten, Mary Beth // Urology Times;3/1/2006, Vol. 34 Issue 3, p4 

    The article reports on the prospective evidence that supports the recognition that erectile dysfunction (ED) may be a sign of future cardiovascular disease in some men. According to Ian M. Thompson, the prospective study of nearly 10,000 men showed that ED is independently associated with...

  • Erectile Dysfunction and Undiagnosed Diabetes, Hypertension, and Hypercholesterolemia. Skeldon, Sean C.; Detsky, Allan S.; Goldenberg, S. Larry; Law, Michael R. // Annals of Family Medicine;Jul/Aug2015, Vol. 13 Issue 4, p331 

    PURPOSE We investigated whether erectile dysfunction, a marker for future cardiovascular disease, is associated with undiagnosed cardiometabolic risk factors among US men. Identifying the presence of these risk factors could lead to earlier initiation of treatment for primary prevention of...

  • Pharmacists tap Net. Callaghan, Dennis // eWeek;9/20/2004, Vol. 21 Issue 38, p34 

    The article focuses on internet-based prescriptions by pharmacists. Handwritten prescriptions hand-carried to pharmacies are still the norm, leading to an estimated 150 million callbacks a year to doctors by pharmacists questioning illegible handwritten prescriptions, as well as 7,000 patient...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics