TITLE

Identification of Thioredoxin-2 as a Regulator of the Mitochondrial Permeability Transition

AUTHOR(S)
Min He; Jiyang Cai; Young-Mi Go; Jennifer M. Johnson; W. David Martin; Jason M. Hansen; Dean P. Jones
PUB. DATE
September 2008
SOURCE
Toxicological Sciences;Sep2008, Vol. 105 Issue 1, p44
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thioredoxin-2 (Trx2) is a multifunctional, mitochondria-specific protein, which inhibits cell death. The mitochondrial permeability transition (MPT) is a distinct mechanism for cell death activated by oxidants and linked to both necrotic and apoptotic morphologies. We studied mitochondria from Trx2 transgenic mice to determine whether Trx2 protects against oxidant-induced MPT. All experiments were performed in isolated mitochondria. Results showed that Trx2 protected against MPT induced by exogenously added peroxide. Unexpectedly, Trx2 also protected against the MPT induced by Ca2+ in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT.
ACCESSION #
33943771

 

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