Cancer and Stem Cells
Tags: STEM cells; CANCER -- Research
Related Articles
- Sox2 expression in breast tumours and activation in breast cancer stem cells. Leis, O; Eguiara, A; Lopez-Arribillaga, E; Alberdi, M J; Hernandez-Garcia, S; Elorriaga, K; Pandiella, A; Rezola, R; Martin, A G // Oncogene;3/15/2012, Vol. 31 Issue 11, p1354
The cancer stem cell (CSC) model does not imply that tumours are generated from transformed tissue stem cells. The target of transformation could be a tissue stem cell, a progenitor cell, or a differentiated cell that acquires self-renewal ability. The observation that induced pluripotency...
- Mouse Models for Cancer Stem Cell Research. Le Cheng; Ramesh, Anirudh V.; Flesken-Nikitin, Andrea; Choi, Jinhyang; Nikitin, Alexander Yu. // Toxicologic Pathology;Jan2010, Vol. 38 Issue 1, p62
The cancer stem cell concept assumes that cancers are mainly sustained by a small pool of neoplastic cells, known as cancer stem cells or tumor initiating cells, which are able to reproduce themselves and produce phenotypically heterogeneous cells with lesser tumorigenic potential. Cancer stem...
- Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1. Zhu, Y.; Sun, Z.; Han, Q.; Liao, L.; Wang, J.; Bian, C.; Li, J.; Yan, X.; Liu, Y.; Shao, C.; Zhao, R. C. // Leukemia (08876924);May2009, Vol. 23 Issue 5, p925
Mesenchymal stem cells (MSCs) have an inhibitory effect on tumor proliferation, but the precise mechanisms are not fully understood. Here, we identified DKK-1 (dickkopf-1), secreted by MSCs and acting as a negative regulator of WNT signaling pathway, to be one of the molecules responsible for...
- Stem cells could cause spread of prostate cancer. // Urology Times;Apr2008, Vol. 36 Issue 4, p23
The article reports on the role of cancer stem cells in spreading the prostate cancer in the body. According to the researchers of the Roswell Park Cancer Institute, the cancer stem cells which hide during the chemotherapy can distribute the cancer in some parts of the body after it will grow...
- Broccoli Compound Targets Breast Cancer Stem Cells. Dye, Dayna // Life Extension;Aug2010, Vol. 16 Issue 8, p14
The article discusses research which was conducted at the University of Michigan and found that a chemical compound called sulforaphane, which is found in broccoli and broccoli sprouts, targets breast cancer stem cells in cell cultures and in mice.
- Cancer stem cells: mirage or reality? Gupta, Piyush B.; Chaffer, Christine L.; Weinberg, Robert A. // Nature Medicine;Sep2009, Vol. 15 Issue 9, p1010
The similarities and differences between normal tissue stem cells and cancer stem cells (CSCs) have been the source of much contention, with some recent studies calling into question the very existence of CSCs. An examination of the literature indicates, however, that the CSC model rests on firm...
- Transient over-expression of estrogen receptor-a in breast cancer cells promotes cell survival and estrogen-independent growth/Effects of estrogen on the proportion of stem cells in the breast. // Current Medical Literature: Breast Cancer;2011, Vol. 23 Issue 4, p131
The article discusses the results of studies that examined the expression of estrogen receptor (ER)-alpha in breast carcinoma. It references two studies published in the "Breast Cancer Research and Treatment" journal. The first study investigated the effect of ER-alpha overexpression in the...
- Cancer stem cells: Invitation to a second round. Dirks, Peter // Nature;7/1/2010, Vol. 466 Issue 7302, p40
The article presents a study on melanoma and cancer cells enriched in CD271, a stem-cell marker. Researchers discovered that CD271-expressing cells could retain and initiate tumour growth in vivo. The findings reflect a perspective different from that of an earlier study which showed that as...
- Largest Organization of Cancer Scientists Adopts New Stem Cell Research Policy. McLemore, Monica R. // Clinical Journal of Oncology Nursing;Oct2005, Vol. 9 Issue 5, p514
Focuses on several primary points included in a position statement adopted by the board of directors at the American Association for Cancer Research which indicate that stem cell research is essential to the advancement of cancer research. Benefits from research on tissue-specific stem cells...
