Fatal thrombosis with activated factor VII in a paediatric patient on extracorporeal membrane oxygenation

Chalwin, Richard P.; Tiruvoipati, Ravindranath; Peek, Giles J.
September 2008
European Journal of Cardio-Thoracic Surgery;Sep2008, Vol. 34 Issue 3, p685
Academic Journal
Abstract: Bleeding remains a potential complication for patients requiring extracorporeal life support systems. Recombinant activated factor VII (rFVIIa) is one of the drugs used in controlling bleeding. Its use is generally found to be safe. We report a paediatric patient who developed fatal thrombosis with the use of rFVIIa whilst on extracorporeal membrane oxygenation and discuss the possible factors that lead to fatal thrombosis.


Related Articles

  • Risk factors associated with peripherally inserted central venous catheter-related large vein thrombosis in neurological intensive care patients. Wilson, Thomas; Brown, Devin; Meurer, William; Stetler, William; Wilkinson, D.; Fletcher, Jeffrey // Intensive Care Medicine;Feb2012, Vol. 38 Issue 2, p272 

    Purpose: Using Virchow's triad as a framework, we sought to identify risk factors independently associated with symptomatic peripherally inserted central venous catheter (PICC)-related large vein thrombosis (PRLVT) in neurological intensive care patients. Methods: A retrospective cohort study...

  • NovoSeven: mode of action and use in acquired haemophilia. von Depka, Mario // Intensive Care Medicine;Oct2002 Supplement 2, Vol. 28, pS222 

    Recombinant activated factor VII (rFVIIa, 'NovoSeven') is indicated for the treatment of spontaneous and surgical bleeding in patients with haemophilia A or B with antibodies to factors VIII or IX (FVIII or FIX) worldwide, and in patients with acquired haemophilia in Europe. In vitro cell models...

  • Letters. Cárdenas Suri, Hisyovi // MEDICC Review;Apr2015, Vol. 17 Issue 2, p5 

    A letter to the editor is presented in response to the article "Zero in on Postpartum Hemorrhage to Reduce Cuba's Maternal Mortality," in the December 2014 issue.

  • Updates in the management of severe coagulopathy in trauma patients. Lynn, Mauricio; Jeroukhimov, Igor; Klein, Yoram; Martinowitz, Uri // Intensive Care Medicine;Oct2002 Supplement 2, Vol. 28, pS241 

    Coagulopathy is the major cause of bleeding-related mortality in patients who survive the operating room. Its association with hypothermia and metabolic acidosis is common and constitutes a vicious cycle. Usually, post-traumatic coagulopathy is an early event and may be present during surgery....

  • Ongoing NovoSeven trials. Erhardtsen, Elisabeth // Intensive Care Medicine;Oct2002 Supplement 2, Vol. 28, pS248 

    Recombinant activated factor VII (rFVIIa, 'NovoSeven' was initially developed for the treatment of bleeding in patients with haemophilia and inhibitors, and is currently licensed in most countries worldwide. The mechanism of action suggests that its enhancing effects in haemostasis are limited...

  • Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy. Mayer, Stephan A. // Intensive Care Medicine;Oct2002 Supplement 2, Vol. 28, pS235 

    Stroke is a major health problem worldwide, causing high morbidity and mortality. Intracerebral hemorrhage (ICH) accounts for 15% of stroke cases in the US and Europe and up to 30% in Asian populations. It is less treatable than other forms of stroke and causes higher morbidity and disability....

  • Haemorrhagic complications of thrombocytopenia and oral anticoagulation: is there a role for recombinant activated factor VII? Kessler, Craig // Intensive Care Medicine;Oct2002 Supplement 2, Vol. 28, pS228 

    Recombinant activated factor VII (rFVIIa, 'NovoSeven') is indicated for the treatment of bleeding in patients with haemophilia and inhibitors to factors VIII or IX. However, by virtue of its ability to promote thrombin generation on the platelet surface rFVIIa may also be effective in...

  • Compression Stocking and DVT in Air Travel Passengers. Walling, Anne D. // American Family Physician;12/15/2001, Vol. 64 Issue 12, p2005 

    Presents a study by J.H. Scurr and others on the deep venous thrombosis (DVT) risk in patients undertaking long airline flights and the efficacy of wearing class-1 elastic compression stockings during the flight to prevent DVT formation. Description of the study and its results; Conclusion that...

  • Optimal Duration for Prophylaxis of Deep Vein Thrombosis: The New Focus. Toulemonde, Francis; Kher, Andr� // Clinical & Applied Thrombosis/Hemostasis;Fall1996, Vol. 2 Issue 4, p285 

    It is usual to stop prophylaxis of most surgical patients at hospital discharge. However, there is increasing evidence that some patients are at risk of thromboembolism after treatment is stopped. Some evidence and several proposals from the literature are presented, but to date, the situation...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics