TITLE

Immune Responses of Healthy Subjects to a Single Dose of Intramuscular Inactivated Influenza A/Vietnam/1203/2004 (H5N1) Vaccine after Priming with an Antigenic Variant

AUTHOR(S)
Goji, Nega Ali; Nolan, Carrie; Hill, Heather; Wolff, Mark; Noah, Diana L.; Williams, Tracy B.; Rowe, Thomas; Treanor, John J.
PUB. DATE
September 2008
SOURCE
Journal of Infectious Diseases;9/1/2008, Vol. 198 Issue 5, p635
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. We administered a single dose of influenza A/Vietnam/1203/2004 (H5N1, clade 1) vaccine to subjects who had received 2 doses of influenza A/Hong Kong/156/1997 (H5N1, clade 0) vaccine in 1998. Methods. Thirty-seven subjects previously vaccinated with a baculovirus-expressed recombinant hemagglutinin A/Hong Kong/156/1997 vaccine in 1998 received a single intramuscular dose of 90 μg of inactivated subvirion A/Vietnam/1203/2004 vaccine in 2006. Serum antibody was measured before vaccination and 28 and 56 days after vaccination. Antibody responses were compared with those measured after one or two 90-μg doses in H5-naive subjects. Results. On day 28 after a single dose, the geometric mean titer (GMT) of hemagglutination-inhibition antibody in primed subjects was 64.0 (95% confidence interval [CI], 37.8 -108.5), with 68% responding (4-fold increase in antibody level to a titer of ⩾1:40). In contrast, H5-naive subjects who received two 90-μg doses had a day 56 (28 days after the second dose) GMT of 27.7 (95% CI, 20.3-38.0), with only 43% responding. Conclusions. This study suggests that priming can result in immune responses to a single dose of an antigenically variant strain of H5N1 influenza virus and could be a useful strategy for pandemic control. Trial registration. ClinicalTrials.gov identifier: NCT00240903.
ACCESSION #
33773112

 

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