2008 - Low-dose hydrocortisone did not improve survival in patients with septic shock but reversed shock earlier
- Corticosteroids in the Treatment of Severe Sepsis and Septic Shock in Adults. Annane, Djillali; Bellissant, Eric; Bollaert, Pierre-Edouard; Briegel, Josef; Confalonieri, Marco; De Gaudio, Raffaele; Keh, Didier; Kupfer, Yizhak; Oppert, Michael; Meduri, G. Umberto // JAMA: Journal of the American Medical Association;6/10/2009, Vol. 301 Issue 22, p2362
The article discusses a study which investigated the risks and benefits of corticosteroid treatment in severe sepsis and septic shock. The study included 17 randomized and quasi-randomized trials of corticosteroids compared to placebo in adult patients. In 12 trials, study authors found that...
- No additional benefit of intensive insulin therapy in patients treated with hydrocortisone for septic shock. // Endocrine Today;Feb2010, Vol. 8 Issue 2, p34
The article discusses research on the benefits of intensive insulin therapy in patients who are under hydrocortisone treatment regimen for septic shock, published in the 2010 issue of the "Journal of the American Medical Association."
- Early goal-directed therapy reduced mortality and multiorgan dysfunction in severe sepsis or septic shock. Natanson, Charles; Danner, Robert L. // ACP Journal Club;May/Jun2002, Vol. 136 Issue 3, p90
Comments on a study which examined early goal-directed therapy in the treatment of severe sepsis and septic shock. Outcome measures; Occurrence of death attributable to sudden cardiovascular collapse in the early goal-directed therapy (EGDT) group; Benefits of EGDT to patients with severe...
- The Circle Continues Unbroken: Now Corticosteroids Are Not Effective for Septic Shock. // Clinical Infectious Diseases;6/1/2008, Vol. 46 Issue 11, pvi
The article reports on the therapeutic effect of corticosteroid administration on patients with sepsis. Study shows that stress-dose steroid therapy should be given only in septic shock after blood pressure is determined to be poorly responsive to fluid and vasopressor therapy. It reveals that...
- Considering CORTICUS: Hydrocortisone in Septic Shock. Akhtar, Saadia R. // Critical Care Alert;Apr2008, Vol. 16 Issue 1, p3
A multicenter, randomized, double-blind, placebo-controlled trial of hydrocortisone replacement in patients with septic shock found no mortality benefit in those patients with inadequate baseline response to corticotropin stimulation.
- Hydrocortisone and fludrocortisone improved 28-day survival in septic shock and adrenal insufficiency. Beigel, John; Eichacker, Peter // ACP Journal Club;Mar/Apr2003, Vol. 138 Issue 2, p44
Presents a study that analyzed the effectiveness of replacement therapy with hydrocortisone and fludrocortisone in patients with septic shock and relative adrenal insufficiency. Background of the patients who participated in the study; Survival rate with treatment in the corticotropin-responder...
- Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock. Laviolle, Bruno; Annane, Djillali; Fougerou, Claire; Bellissant, Eric // Intensive Care Medicine;Aug2012, Vol. 38 Issue 8, p1306
Purpose: The benefits of low-dose steroids in septic shock remain controversial. We investigated if these low doses were able to induce their expected hormonal effects by analyzing the biological modifications observed during the study, which first demonstrated the survival benefit of low-dose...
- Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock. Rivers, Emanuel; Nguyen, Bryant; Havstad, Suzanne; Ressler, Julie; Muzzin, Alexandria; Knoblich, Bernhard; Peterson, Edward; Tomlanovich, Michael // New England Journal of Medicine;11/8/2001, Vol. 345 Issue 19, p1368
Background: Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy...
- Early goal-directed therapy versus 'early', 'goal-directed' therapy. Saleh, Ahmad // Intensive Care Medicine;Sep2015, Vol. 41 Issue 9, p1723
A letter to the editor is presented in response to the article "A Systematic Review and Meta-analysis of Early Goal-directed Therapy for Septic Shock: The ARISE, ProCESS and ProMISe Investigators" by D. C. Angus and colleagues in the 2015 issue.