2008 - Intensive insulin therapy and starch (HES 200/0.5) had some risk and no clear benefit in severe sepsis

Cook, Deborah; McIntyre, Lauralyn
June 2008
ACP Journal Club;6/20/2008, Vol. 148 Issue 4, p3
Academic Journal
The article compares intensive insulin therapy (IIT) with conventional therapy for mortality in critically ill patients with severe sepsis or septic shock. It also compares fluid resuscitation with hydroxyethyl starch (HES) with Ringer's lactate (RL). Several clinical trials concluded that IIT increased hypoglycemia and adverse events compared with conventional therapy. Fluid resuscitation with HES increased acute renal failure and renal replacement therapy compared with RL.


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