TITLE

A review of modern multiple hypothesis testing, with particular attention to the false discovery proportion

AUTHOR(S)
Farcomeni, Alessio
PUB. DATE
August 2008
SOURCE
Statistical Methods in Medical Research;Aug2008, Vol. 17 Issue 4, p347
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the last decade a growing amount of statistical research has been devoted to multiple testing, motivated by a variety of applications in medicine, bioinformatics, genomics, brain imaging, etc. Research in this area is focused on developing powerful procedures even when the number of tests is very large. This paper attempts to review research in modern multiple hypothesis testing with particular attention to the false discovery proportion, loosely defined as the number of false rejections divided by the number of rejections. We review the main ideas, stepwise and augmentation procedures; and resampling based testing. We also discuss the problem of dependence among the test statistics. Simulations make a comparison between the procedures and with Bayesian methods. We illustrate the procedures in applications in DNA microarray data analysis. Finally, few possibilities for further research are highlighted.
ACCESSION #
33764143

 

Related Articles

  • Using Pathway Signatures as Means of Identifying Similarities among Microarray Experiments. Beltrame, Luca; Rizzetto, Lisa; Paola, Raffaele; Rocca-Serra, Philippe; Gambineri, Luca; Battaglia, Cristina; Cavalieri, Duccio // PLoS ONE;2009, Vol. 4 Issue 1, p1 

    Widespread use of microarrays has generated large amounts of data, the interrogation of the public microarray repositories, identifying similarities between microarray experiments is now one of the major challenges. Approaches using defined group of genes, such as pathways and cellular networks...

  • Justice and Fairness in the Dictator Game. Schurter, Karl; Wilson, Bart J. // Southern Economic Journal;Jul2009, Vol. 76 Issue 1, p130 

    This article uses a laboratory experiment to examine the question of whether justice and fairness are different motivational forces in the dictator game. "Justice" and "fairness" are often used interchangeably because their meanings and usages are so closely linked, despite their distinct...

  • Outperforming Completely Randomized Designs. Goos, Peter; Vandebroek, Martina // Journal of Quality Technology;Jan2004, Vol. 36 Issue 1, p12 

    Split-plot designs have become increasingly popular in industrial experimentation because some of the factors under investigation are often hard-to-change. It is well-known that the resulting compound symmetric error structure not only affects estimation and inference procedures but also the...

  • ALTERNATIVE INFERENCE MODELS BASED ON MATCHING FOR A WEIGHTED INDEX OF NOMINAL SCALE RESPONSE AGREEMENT. Hubert, Lawrence J. // Quality & Quantity;Dec80, Vol. 14 Issue 6, p711 

    This article focuses on alternative inference models which are based on matching for a weighted index of nominal scale response agreement. The possible extensions of the basic Cohen and Scott matching paradigms are substantial. In fact, other generalizations exist but many of these go beyond the...

  • A NEW APPARATUS TO STUDY BEHAVIOR OF TRIATOMINES UNDER LABORATORY CONDITIONS. Aldana, Elis; Otalora, Fernando; Abramson, Charles I. // Psychological Reports;Jun2005 Part 1, Vol. 96 Issue 3, p825 

    A new apparatus is described to study a wide range of behavior in the vectors of Chagas's disease. The device is relatively inexpensive and easy to construct. A wide range of independent variables can be studied, including potential attractants, repellents, blood, and blood products under...

  • A robust optimization approach to experimental design for model discrimination of dynamical systems. Skanda, Dominik; Lebiedz, Dirk // Mathematical Programming;Oct2013, Vol. 141 Issue 1/2, p405 

    A high-ranking goal of interdisciplinary modeling approaches in science and engineering are quantitative prediction of system dynamics and model based optimization. Quantitative modeling has to be closely related to experimental investigations if the model is supposed to be used for mechanistic...

  • Exploring Verbalization and Collaboration during Usability Evaluation with Children in Context. Khanum, Mohammadi Akheela; Trivedi, Munesh C. // International Journal of Computer Science Issues (IJCSI);Jan2013, Vol. 10 Issue 1, p485 

    In this paper, we investigate the effect of context on usability evaluation. The focus is on how children behave and perform when they are tested in different settings. Two most commonly applied usability evaluation methods: the think-aloud and constructive interactions are applied to the...

  • High Speed Multi-Wavelength Pyrometry and Emissivity Measurement of Shocked Metals. David Partouche-Sebban // AIP Conference Proceedings;2004, Vol. 706 Issue 1, p1293 

    In most shock experiments, the sample temperature needs to be measured in less than a microsecond. Currently, high-speed optical pyrometry seems to be the best way to perform this measurement. This is a challenge for any metal, particularly so at low shock pressures and for temperatures below...

  • Testes multiambientais ua seleção de genótipos de arroz utilizando o modelo de regressão nos sítios ou locais. Ramos, Lina Maria; Sanches, Adhemar; Cotes, José Miguel // Ciência Rural;ene2009, Vol. 39 Issue 1, p52 

    The analysis of genotype x environment interaction in plant breeding have been enlarged with new methodologies in the last decade, improving its efficiency on the selection of genotypes under different environmental conditions. The objective of this research was to analyze the yield and...

Share

Read the Article

Courtesy of NEW JERSEY STATE LIBRARY

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics