Neurobehavioural effects of occupational exposure to cadmium: a cross sectional epidemiological study

Viaene, M. K.; Masschelein, R.; Leenders, J.; De Groof, M.; Swerts, L. J. V. C.; RoeIs, H. A.
January 2000
Occupational & Environmental Medicine;Jan2000, Vol. 57 Issue 1, p19
Academic Journal
A patient with unexplained minor behavioural changes associated with an axonal sensorimotor polyneuropathy had a history of chronic occupational exposure to cadmium (Cd). Although animal studies have shown that Cd is a potent neurotoxicant, little is known about its toxicity for the human central nervous system. The aim of this study was to investigate the toxic potential of chronic occupational exposure to Cd on neurobehavioural functions. A cross sectional epidemiological study was conducted in a group of Cd workers and an age matched control group. Eighty nine adult men (42 exposed to Cd and 47 control workers) were given a blinded standardised examination that consisted of computer assisted neurobehavioural tests (neurobehavioural examination system), a validated questionnaire to assess neurotoxic complaints (neurotoxicity symptom checklist-60, NSC-60), and a standardised self administered questionnaire to detect complaints consistent with peripheral neuropathy and dysfunction of the autonomic nervous system. Historical and current data on biomonitoring of exposure to Cd, either the highest value of Cd in urine (CdU in μg Cd/g creatinine) of each Cd worker during work (CdUmax) or the current value (CdUcurrent) of each control, were available as well as data on microproteinuria. Cd workers (CdUmax: mean (range), 12.6 (0.4-38.4)) performed worse than the controls (CdUcurrent: mean (range), 0.7 (0.1-2.0)) on visuomotor tasks, symbol digit substitution (p=0.008), and simple reaction time to direction (p=0.058) or location (p=0.042) of a stimulus. In multiple linear regression analysis, symbol digit substitution, simple direction reaction time test, and simple location reaction time test were significantly related to CdUmax, (&=0.35 ( p<0.001), &= 0.25 (p=0.012), and &=0.23 (p=0.021) respectively). More complaints consistent with peripheral neuropathy (p=0.004), complaints about equilibrium (p=0...


Related Articles

  • Psychometric Evaluation of Two Scales Assessing Functional Status and Peripheral Neuropathy Associated With Chemotherapy for Ovarian Cancer: A Gynecologic Oncology Group Study. Almadrones, Lois; McGuire, Deborah B.; Walczak, Janet Ruth; Florio, Colleen M.; Tian, Chunqiao // Oncology Nursing Forum;May/Jun2004, Vol. 31 Issue 3, p615 

    Purpose/Objectives: To evaluate the psychometric properties of two adapted scales, one for functional status and one for peripheral neuropathy secondary to neurotoxic chemotherapy. Design: Repeated measures methodologic design conducted within a Gynecologic Oncology Group (GOG) phase III...

  • New mutations, genotype phenotype studies and manifesting carriers in giant axonal neuropathy. Houlden, Henry; Groves, Mike; Miedzybrodzka, Zosia; Roper, Helen; Willis, Tracey; Winer, John; Cole, Gaynor; Reilly, Mary M. // Journal of Neurology, Neurosurgery & Psychiatry;Nov2007, Vol. 78 Issue 11, p1267 

    Giant axonal neuropathy (GAN; MIM 256850) is a severe childhood onset autosomal recessive sensorimotor neuropathy affecting both the peripheral nerves and the central nervous system. Bomont and colleagues identified a novel ubiquitously expressed gene they named Gigaxonin on chromosome 16q24 as...

  • Deficits in compensatory trajectory adjustments after unilateral sensorimotor stroke. Fisher, B. E.; Winstein, C. J.; Velicki, M. R. // Experimental Brain Research;Jun2000, Vol. 132 Issue 3, p328 

    In a previous study, we demonstrated that the time-course for amplitude specification of goal-directed aiming movements is similar for individuals with and without a unilateral sensorimotor (SM) area lesion. However, subjects with a SM lesion performing with the arm ipsilateral to the side of...

  • Neonatal Aspects: Is There Continuity? Stanojevic, Milan // Donald School Journal of Ultrasound in Obstetrics & Gynecology;Apr-Jun2012, Vol. 6 Issue 2, p189 

    During the 9 months between conception and birth, the fetal brain is transformed from instructions in genes to a complex, highly differentiated organ. The human central nervous system (CNS) changes from a microscopic band of embryonic neuroblasts to a 350 gm mass with more than 109...

  • Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke: influence of enriched environment. Rickhag, Mattias; Deierborg, Tomas; Patel, Shutish; Ruscher, Karsten; Wieloch, Tadeusz // Journal of Cerebral Blood Flow & Metabolism;Mar2008, Vol. 28 Issue 3, p551 

    Injury to the brain (e.g., stroke) results in a disruption of neuronal connectivity and loss of fundamental sensori-motor functions. The subsequent recovery of certain functions involves structural rearrangements in areas adjacent to the infarct. This remodeling of the injured brain requires...

  • Ahypothesis on the role of perturbation size on the human sensorimotor adaptation. Yavari, Fatemeh; Towhidkhah, Farzad; Darainy, Mohammad // Frontiers in Computational Neuroscience;Mar2014, Vol. 8, p1 

    The article presents a study which mentions a hypothesis on the possible adaptation mechanisms employed in the brain depending on error size. It mentions that the proposed hypothesis provides an improved understanding of motor adaptation mechanism in brain. It is inferred that deafferented...

  • Decoding Hindlimb Movement for a Brain Machine Interface after a Complete Spinal Transection. Manohar, Anitha; Flint, Robert D.; Knudsen, Eric; Moxon, Karen A. // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    Stereotypical locomotor movements can be made without input from the brain after a complete spinal transection. However, the restoration of functional gait requires descending modulation of spinal circuits to independently control the movement of each limb. To evaluate whether a brain-machine...

  • Are movement disorders and sensorimotor injuries pathologic synergies? When normal multi-joint movement synergies become pathologic. Santello, Marco; Lang, Catherine E. // Frontiers in Human Neuroscience;Jan2015, Vol. 8, p1 

    The intact nervous system has an exquisite ability to modulate the activity of multiple muscles acting at one or more joints to produce an enormous range of actions. Seemingly simple tasks, such as reaching for an object or walking, in fact rely on very complex spatial and temporal patterns of...

  • Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype. Mathey, Emily K.; Park, Susanna B.; Hughes, Richard A. C.; Pollard, John D.; Armati, Patricia J.; Barnett, Michael H.; Taylor, Bruce V.; Dyck, P. James B.; Kiernan, Matthew C.; Lin, Cindy S. -Y. // Journal of Neurology, Neurosurgery & Psychiatry;Sep2015, Vol. 86 Issue 9, p973 

    Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory neuropathy, classically characterised by a slowly progressive onset and symmetrical, sensorimotor involvement. However, there are many phenotypic variants, suggesting that CIDP may not be a discrete disease...


Read the Article


Sign out of this library

Other Topics