New review focuses on emergency contraception

Long, Abigail; Jordan, Beth
August 2008
Contraceptive Technology Update;Aug2008, Vol. 29 Issue 8, p90
Academic Journal
A new review of clinical trial results indicates mifepristone is the most effective emergency contraceptive (EC); however, the drug isn't approved in the United States for this use. ∎ Most of the trials studied mifepristone in two levels: low dose and middle dose. Levonorgestrel trials included a single dose of 1.5 mg or two doses of 0.75 mg given 12 hours apart. Mifepristone, given in the middle dose, was the most effective hormonal regimen in preventing pregnancy. ∎ More pregnancies occurred with levonorgestrel EC than with mid-dose mifepristone or low-dose mifepristone. Single-dose levonorgestrel EC had the same effectiveness as the split dose; levonorgestrel, however, was more effective than the Yuzpe regimen in preventing pregnancy.


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