Does Autofluorescence Imaging Videoendoscopy System Improve the Colonoscopic Polyp Detection Rate?—A Pilot Study

Matsuda, Takahisa; Saito, Yutaka; Fu, Kuang-I; Uraoka, Toshio; Kobayashi, Nozomu; Nakajima, Takeshi; Ikehara, Hisatomo; Mashimo, Yumi; Shimoda, Tadakazu; Murakami, Yoshitaka; Parra-Blanco, Adolfo; Fujimori, Takahiro; Saito, Daizo
August 2008
American Journal of Gastroenterology;Aug2008, Vol. 103 Issue 8, p1926
Academic Journal
OBJECTIVES: Colonoscopy is considered the gold standard for the detection of colorectal polyps; however, polyps can be missed with conventional white light (WL) colonoscopy. The aim of this pilot study was to evaluate whether a newly developed autofluorescence imaging (AFI) system can detect more colorectal polyps than WL. METHODS: A modified back-to-back colonoscopy using AFI and WL was conducted for 167 patients in the right-sided colon including cecum, ascending and transverse colon by a single experienced colonoscopist. The patient was randomized to undergo the first colonoscopy with either AFI or WL (group A: AFI-WL, group B: WL-AFI). The time needed for both insertion and examination for withdrawal and all lesions detected in the right-sided colon were recorded. RESULTS: Eighty-three patients were randomized to group A and 84 to group B. The total number of polyps detected by AFI and WL colonoscopy was 100 and 73, respectively. The miss rate for all polyps with AFI (30%) was significantly less than that with WL (49%) ( P= 0.01). CONCLUSIONS: AFI detects more polyps in the right-sided colon compared to WL colonoscopy.


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