Patch test triggering recurrence of distant dermatitis: the flare-up phenomenon

Daniele Torchia; Chiara Capretti; Benedetto Pizzo; Stefano Francalanci
August 2008
CMAJ: Canadian Medical Association Journal;8/12/2008, Vol. 179 Issue 4, p341
Academic Journal
The article focuses on the patch test conducted to a 37-year-old woman with pruritic, vesiculobullous eruption on her neck caused by a suspected acute allergic contact dermatitis. The test was performed on her back using scrapings from the ebony pendant. Rashes resembling the shape of the pendant was developed on the region where the test was conducted. It proved that the presence of macassar quinone, the only known allergen of the ebony was the cause of allergic contact dermatitis. Once the allergen penetrated the skin and entered the blood stream, it could reactivate specific memory T cells resulting to skin inflammation.


Related Articles

  • 6. Contact allergic reactions in patients with atopic eczema. McFadden, John // Acta Dermato-Venereologica;Nov2005 Supplement 2, Vol. 85, p28 

    The article investigates the susceptibility of atopic dermatitis patients to contact dermatitis. AD patients become sensitized to contact allergens. Chromate, thiuram mix, nickel sulphate, perfume mix, neomycin and wool alcohols are common allergens in atopic eczema patients. All in all,...

  • Determination of In Vivo Dose Response and Allergen-Specific T Cells in Subjects Contact-Sensitized to Squaric Acid Dibutyl Ester. Camouse, Melissa M.; Swick, Alan R.; Ryan, Cindy A.; Hulette, Ben; Gerberick, Frank; Tinkle, Sally S.; Nedorost, Susan T.; Cooper, Kein D.; Stevensa, Seth R.; Baron, Elma D. // Dermatitis (Decker Publishing);Mar/Apr2008, Vol. 19 Issue 2, p95 

    Background: Squaric acid dibutyl ester (SADBE) is a known contact sensitizer, but dose-response data are not defined. Objective: To determine the relationship between sensitization dose and contact hypersensitivity (CHS) response to SADBE in human volunteers. The study also aimed to investigate...

  • IFN-γ and TNF-α are involved in urushiol-induced contact hypersensitivity in mice. Wakabayashi, Toshiteru; Hu, Dong-Liang; Tagawa, Yoh-Ichi; Sekikawa, Kenji; Iwakura, Yoichiro; Hanada, Katsumi; Nakane, Akio // Immunology & Cell Biology;Feb2005, Vol. 83 Issue 1, p18 

    Contact hypersensitivity (CHS) is a cutaneous T-cell-mediated immunological reaction to applied haptens. Activated antigen-specific T cells release several cytokines and chemokines followed by the recruitment of inflammatory cells and skin damage. CD8+ T cells and CD4+ T cells have been involved...

  • Modulation of Skin Norepinephrine Turnover by Allergen Sensitization: Impact on Contact Hypersensitivity and T Helper Priming. Maestroni, Georges J.M. // Journal of Investigative Dermatology;Jan2004, Vol. 122 Issue 1, p119 

    The information gathered by dendritic cells during the innate immune response is determinant for the type and strength of the adaptive response. We showed that the sympathetic neurotransmitter norepinephrine influences dendritic cell migration and T helper priming via α- and...

  • Abrogation of High-Affinity IgE Receptor-Mediated Mast Cell Activation at the Effector Phase Prevents Contact Hypersensitivity to Oxazolone. Kobayashi, Maiko; Nunomura, Satoshi; Gon, Yasuhiro; Endo, Daisuke; Kishiro, Sachiko; Fukunaga, Makiko; Kitahata, Yuko; Terui, Tadashi; Ra, Chisei // Journal of Investigative Dermatology;Mar2010, Vol. 130 Issue 3, p725 

    Inflammatory mediators released from mast cells (MCs) through engagement of the high-affinity receptor for IgE (FcɛRI) have pivotal roles in chemical allergen-induced contact hypersensitivity (CHS) reactions, which suggests that the blockade of MC activation through FcɛRI stimulation may...

  • Allergic Contact Dermatitis in the Hamster. Maguire Jr., Henry C. // Journal of Investigative Dermatology;Aug80, Vol. 75 Issue 2, p166 

    Allergic contact dermatitis to strong, low molecular weight contact allergens can regularly be induced in the hamster. By its clinical course, histopathology and susceptibility to intensification with complete Freund's adjuvant, this hypersensitivity appears congruent with the allergic contact...

  • Contact Dermatitis. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p159 

    The article presents an encyclopedia entry for contact dermatitis, a term used for skin dermatitis reactions instigated by allergen or irritant. The irritant contact dermatitis is a nonimmunologic inflammatory response to contact irritant characterized by redness and sharply demarcated vesicles....

  • Induction of Contact Sensitivity to a Broad Variety of Allergens with Haptenized Macrophages. von Blomeberg-van der Flier, Mary; Scheper, Rik J.; Boerrigter, Gijs H.; Polak, Ladislav // Journal of Investigative Dermatology;Aug84, Vol. 83 Issue 2, p91 

    Using guinea pigs an analysis could be made of various aspects of contact sensitivity (CS) induced by subcutaneous injection of syngeneic haptenized macrophages (oil-induced peritoneal exudate cells, PEC) as compared to epicutaneous sensitization. Very little PEC-bound hapten...

  • Contact allergies.  // Pulse;3/3/2009, Vol. 70 Issue 7, p27 

    A quiz concerning the types of allergen that cause contact dermatitis is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics