Anemia of chronic disease: A harmful disorder or an adaptive, beneficial response?

Zarychanski, Ryan; Houston, Donald S.
August 2008
CMAJ: Canadian Medical Association Journal;8/12/2008, Vol. 179 Issue 4, p333
Academic Journal
The article discusses an analysis of the notion that anemia of chronic disease is harmful and a consequence of systemic illness. Although poor prognosis in many clinical disorders is one factor of this prevailing notion, the authors argue that anemia of chronic disease is a beneficial adaptive physiological response of the body to an underlying disease state such as an inflammatory disease. However, it is suggested that restraint must be advocated in treating such type of anemia and future therapeutic trials should try to characterize its underlying cause.


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