An exploration of the association between frailty and muscle fatigue

Theou, Olga; Jones, Gareth R.; Overend, Tom J.; Kloseck, Marita; Vandervoort, Anthony A.
August 2008
Applied Physiology, Nutrition & Metabolism;Aug2008, Vol. 33 Issue 4, p651
Academic Journal
Frailty is increasingly recognized as a geriatric syndrome that shares common biomedical determinants with rapid muscle fatigue: aging, disease, inflammation, physical inactivity, malnutrition, hormone deficiencies, subjective fatigue, and changes in neuromuscular function and structure. In addition, there is an established relationship between muscle fatigue and core elements of the cycle of frailty as proposed by Fried and colleagues (sarcopenia, neuroendocrine dysregulation and immunologic dysfunction, muscle weakness, subjective fatigue, reduced physical activity, low gait speed, and weight loss). These relationships suggest that frailty and muscle fatigue are closely related and that low tolerance for muscular work may be an indicator of frailty phenotype. On constate de plus en plus que la fragilité est un syndrome gériatrique dont les causes biomédicales sont les mêmes que celles associées à la fatigue musculaire hâtive : le vieillissement, la maladie, l’inflammation, l’inactivité physique, la malnutrition, les carences hormonales, la fatigue subjective et les modifications structurelles et fonctionnelles de l’appareil neuromusculaire. Qui plus est, on connaît bien la relation entre la fatigue musculaire et les principaux constituants du cycle de fragilité défini par Fried et collaborateurs (sarcopénie, dérèglement neuroendocrinien et dysfonction immunitaire, fatigue musculaire, fatigue subjective, diminution de l’activité physique, faible vitesse de marche, perte de poids). D’après ces relations, on relie la fragilité et la fatigue musculaire et on reconnaît une faible tolérance à l’exercice musculaire comme un signe du phénotype de la fragilité.


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