TITLE

Sporadic Pancreatic Polypeptide Secreting Tumors (PPomas) of the Pancreas

AUTHOR(S)
Kuo, Samuel C. L.; Gananadha, Sivakumar; Scarlett, Christopher J.; Gill, Anthony; Smith, Ross C.
PUB. DATE
August 2008
SOURCE
World Journal of Surgery;Aug2008, Vol. 32 Issue 8, p1815
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Sporadic pancreatic neuroendocrine tumors, which predominantly secrete pancreatic polypeptide (PPoma), are rare and have not been associated with a clinical syndrome. A wider understanding of their pathological features and behavior is needed. Four PPoma patients who presented with nonspecific abdominal pain are described. Their diagnosis was established by the presence of an enhancing solitary pancreatic tumor on computed tomography (CT) and elevated fasting pancreatic polypeptide hormone levels. Patient 1 was treated with a pancreatoduodenectomy because of elevation of serum CEA level. Two of the cases underwent enucleation because of prolonged stable CT appearance. Patient 4 underwent distal pancreatectomy for a pancreatic neck tumor causing ductal obstruction and distal parenchymal atrophy. All cases had benign histological features apart from patient 1 whose tumor demonstrated occasional mitotic activity. These tumors have not recurred after a median of 49 (range, 35–57) months. The protein expression in the tumor tissue was measured by SELDI-TOF MS and was different than the profile of pancreatic adenocarcinoma that was previously demonstrated in our laboratory. This may lead to future helpful diagnostic testing on fine needle aspirates. Resection of sporadic PPomas presenting as a solitary well-defined mass with benign histological features results in good long-term survival.
ACCESSION #
33372911

 

Related Articles

  • Surgical Experience with Functioning Pancreatic Neuroendocrine Tumors. Matthews, Brent D.; Smith, Trina I.; Kercher, Kent W.; Holder Jr., Walter D.; Heniford, B. Todd // American Surgeon;Aug2002, Vol. 68 Issue 8, p660 

    Pancreatic islet-cell tumors (ICTs) are rare malignancies usually recognized by specific clinical endocrinopathies. The purpose of this study is to evaluate our surgical experience with functioning pancreatic ICT in an academic referral center. Twenty patients (male:female 12:8) with a mean age...

  • StatBite Pancreatic Neuroendocrine Tumors: Incidence by Age and Sex.  // JNCI: Journal of the National Cancer Institute;Apr2011, Vol. 103 Issue 8, p626 

    The article discusses research being done on the incidence and prognosis of pancreatic neuroendocrine tumors (PNETs). It references a study by T. R. Halfdanarson and colleagues in a 2008 issue of the journal "Annals of Oncology." Tumors developing from PNETs are rare with an overall incidence of...

  • Surgical management of pancreatic neuroendocrine tumors. Kimura, Wataru; Tezuka, Koji; Hirai, Ichiro // Surgery Today;Oct2011, Vol. 41 Issue 10, p1332 

    This study outlines the surgical management and clinicopathological findings of pancreatic neuroendocrine tumors (P-NETs). There are various surgical options, such as enucleation of the tumor, spleen-preserving distal pancreatectomy, distal pancreatectomy with splenectomy, pancreatoduodenectomy,...

  • SOMATOSTATINOMA OF THE PANCREAS -- DIFFICULTIES IN PREOPERATIVE DIAGNOSIS -- A CASE REPORT. Dranka-Bojarowska, Daria; Olakowski, Marek; Jabłońska, Beata; Lampe, Paweł // Polish Surgery / Chirurgia Polska;2006 Supplement, Vol. 8, p16 

    This study presented a case of a 51-year-old male patient who underwent surgery due to somatostatinoma of pancreas. Somatostatinoma is the rarest neuroendocrine tumor of the digestive system. Despite many preoperative diagnostic examinations it was impossible to answer the question of...

  • Pancreatic Neuroendocrine Tumors in Glucagon Receptor-Deficient Mice. Run Yu; Dhall, Deepti; Nissen, Nicholas N.; Cuiqi Zhou; Song-Guang Ren // PLoS ONE;2011, Vol. 6 Issue 8, p1 

    Inhibition of glucagon signaling causes hyperglucagonemia and pancreatic a cell hyperplasia in mice. We have recently demonstrated that a patient with an inactivating glucagon receptor mutation (P86S) also exhibits hyperglucagonemia and pancreatic a cell hyperplasia but further develops...

  • Endoscopic Ultrasound Is Highly Accurate and Directs Management in Patients With Neuroendocrine Tumors of the Pancreas. Anderson, Michelle A.; Carpenter, Steven; Thompson, Norman W.; Nostrant, Timothy T.; Elta, Grace H.; Scheiman, James M. // American Journal of Gastroenterology;Sep2000, Vol. 95 Issue 9, p2271 

    OBJECTIVE: Preoperative localization of pancreatic neuroendocrine tumors with traditional imaging fails in 40-60% of patients. Endoscopic ultrasound (EUS) is highly sensitive in the detection of these tumors. Previous reports included relatively few patients or required the collaboration of...

  • A NEW INCOME IN PEDIATRIC PATHOLOGY: GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS. PART I: PANCREATIC TUMORS. DIACONESCU, Smaranda; OLARU, Claudia; GIMIGA, Nicoleta; BURLEA, M.; IONIUC, Ileana; STRATICIUC-CIONGRADI, Iulia // International Journal of Medical Dentistry;Jan-Mar2013, Vol. 17 Issue 1, p22 

    Gastroenteropancreatic neuroendocrine tumors (GEP NET) represent a heterogenous group of neoplasms: carcinoids (serotoninomas) and gastroenteropancreatic (insulinomas, gastrinomas, VIPomas, glucagonomas, somatostatinomas) respectively, unified by their origin (neuroendocrine cells), histology...

  • Resection of the uncinate process of the pancreas due to a ganglioneuroma. Poves, Ignasi; Burdío, Fernando; Martínez-Serrano, María de los Angeles; Aguilar, Guadalupe; Grande, Luís; Nagaya, Masaki // World Journal of Gastroenterology;9/14/2009, Vol. 15 Issue 34, p4334 

    A 33-year-old woman who presented with epigastric discomfort and diarrhea underwent an abdominal ultrasound (US). This investigation and subsequent contrast-enhanced computed tomography, magnetic resonance imaging and endoscopic US with fine needle aspiration (FNA) revealed a 40 mm...

  • Neuroendocrine gastroenteropancreatic tumors: ESMO Clinical Recommendations for diagnosis, treatment and follow-up. Oberg, K.; Jelic, S. // Annals of Oncology;May2008 Supplement 2, Vol. 19 Issue 0, pii104 

    The article presents the clinical recommendations of the European Society of Medical Oncology (ESMO) for the diagnosis, treatment and follow-up of patients with neuroendocrine gastroenteropancreatic (GEP) tumors. Data on the incidence of neuroendocrine GEP is given. Diagnostic procedures include...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics