Collagen Deposition Limits Immune Reconstitution in the Gut

Estes, Jacob; Baker, Jason V.; Jason M.&Brenchley; Khoruts, Alex; Barthold, Jacob L.; Bantle, Anne; Reilly, Cavan S.; Beilman, Gregory J.; George, Mark E.; Douek, Daniel C.; Haase, Ashley T.; Schacker, Timothy W.
August 2008
Journal of Infectious Diseases;8/15/2008, Vol. 198 Issue 4, p456
Academic Journal
Despite suppression of human immunodeficiency virus (HIV) replication by antiretroviral therapy, reconstitution of CD4+ cells is variable and incomplete, particularly in gut-associated lymphatic tissues (GALT). We have previously shown that immune activation and inflammation in HIV-infected and simian immunodeficiency virus- infected lymph nodes results in collagen deposition and disruption of the lymphatic tissue architecture, and this damage contributes to CD4+ cell depletion before treatment and affects the extent of immune reconstitution after treatment. In the present study, we compared collagen deposition and the extent of depletion and reconstitution of total CD4+ cells and subsets in peripheral blood, lymph nodes, and inductive and effector sites in GALT. We show that CD4+ cell depletion in GALT correlates with the rapidity and greater magnitude of collagen deposition in this compartment, compared with that in peripheral lymph nodes, and that although treatment does not restore CD4+ cells to effector sites, treatment in the early stages of infection can increase CD4+ central memory cells in Peyer patches.


Related Articles

  • New Antiretroviral for HIV Infection. Gangel, Elaine Kierl // American Family Physician;3/1/2002, Vol. 65 Issue 5, p987 

    Reports on the approval of tenofovir dioproxil fumarate to treat patients with human immunodeficiency virus infection by the United States Food and Drug Administration. Description of the drug and its use; Side effects.

  • The Dynamics of T and B Cells in Lymph Node during Chronic Hiv infection: TFH and Hiv, Unhappy Dance Partners? Jung Joo Hong; Kyu-Tae Chang; Villinger, Francois; Apetrei, Cristian; Pancino, Gianfranco // Frontiers in Immunology;11/22/2016, Vol. 7, p1 

    Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to B cell follicles within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we...

  • HIV-1 Envelope Protein gp120 Is Present at High Concentrations in Secondary Lymphoid Organs of Individuals with Chronic HIV-1 Infection. Santosuosso, Michael; Righi, Elda; Lindstrom, Victoria; Leblanc, Pierre R.; Poznansky, Mark C. // Journal of Infectious Diseases;10/1/2009, Vol. 200 Issue 7, p1050 

    The envelope protein of human immunodeficiency virus type 1 (HIV-1)-glycoprotein 120 (gp120)-has been demonstrated to dysregulate T cell function in vitro. We obtained autopsy tissues from individuals with chronic HIV-1 infection to determine whether there was enough gp120 in lymphoid tissues...

  • Animal Models Used for the Evaluation of Antiretroviral Therapies. P. Dias, Andreia S.; Bester, Megan J.; Britz, Rozane F.; Apostolides, Zeno // Current HIV Research;Oct2006, Vol. 4 Issue 4, p431 

    Several animal models for the study of HIV/AIDS have been established and characterized and have been widely used to study the pathogenesis of HIV/AIDS as well as vaccine development. The purpose of this study was to review the literature and identify the animal models most frequently used for...

  • Absence of Erythrocyte-Associated HIV-1 In Vivo. Fierer, Daniel Seth; Vargas Jr., Jesus; Patel, Niraj; Clover, Geoffrey // Journal of Infectious Diseases;8/15/2007, Vol. 196 Issue 4, p587 

    A recent study found high levels of human immunodeficiency virus type 1 (HIV-1) bound to erythrocytes in HIV-1-infected patients with long-term undetectable plasma HIV-1 loads, potentially representing a novel and important reservoir of HIV-1 infection. To attempt to confirm this finding, we...

  • Persistence of HIV in Gut-Associated Lymphoid Tissue despite Long-Term Antiretroviral Therapy. Tae-Wook Chun; Nickle, David C.; Justement, A Jesse S.; Meyers, Jennifer H.; Roby, Gregg; Hallahan, Claire W.; Kottilil, Shyam; Moir, Susan; Mican, Joann M.; Mullins, James I.; Ward, Douglas J.; Kovacs, Joseph A.; Mannon, Peter J.; Fauci, Anthony S. // Journal of Infectious Diseases;3/1/2008, Vol. 197 Issue 5, p714 

    Human immunodeficiency virus (HIV) persists in peripheral blood mononuclear cells despite sustained, undetectable plasma viremia resulting from long-term antiretroviral therapy. However, the source of persistent HIV in such infected individuals remains unclear. Given recent data suggesting high...

  • Concordant HIV Infection and Visceral Leishmaniasis in Ethiopia: The Influence of Antiretroviral Treatment and Other Factors on Outcome. ter Horst, Rachel; Collin, Simon M.; Ritmeijer, Koert; Bogale, Adey; Davidson, Robert N. // Clinical Infectious Diseases;6/1/2008, Vol. 46 Issue 11, p1702 

    Background. Coinfection with human immunodeficiency virus (HIV) and Leishmania donovani visceral leishmaniasis (VL) in Africa is an emerging, poorly understood disease. Methods. We evaluated 356 consecutive patients coinfected with HIV and VL treated in Humera, northwest Ethiopia, from February...

  • Early Treatment and HIV-1 Reservoirs: A Stitch in Time? Henrich, Timothy J.; Gandhi, Rajesh T. // Journal of Infectious Diseases;Oct2013, Vol. 208 Issue 8, p1189 

    The article presents the author's comments on the implications of antiretroviral therapy (ART) during acute human immunodeficiency virus type 1 (HIV-1) infection on viral reservoirs. It specifically refers to a study which examined HIV-1 nucleic acid levels and T-cell activation in patients who...

  • Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS. Savarino, Andrea; Pistello, Mauro; D'Ostilio, Daniela; Zabogli, Elisa; Taglia, Fabiana; Mancini, Fabiola; Ferro, Stefania; Matteucci, Donatella; De Luca, Laura; Barreca, Maria Letizia; Ciervo, Alessandra; Chimirri, Alba; Ciccozzi, Massimo; Bendinelli, Mauro // Retrovirology;2007, Vol. 4, p79 

    Background: Treatment of feline immunodeficiency virus (FIV) infection has been hampered by the absence of a specific combination antiretroviral treatment (ART). Integrase strand transfer inhibitors (INSTIs) are emerging as a promising new drug class for HIV-1 treatment, and we evaluated the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics