Human Genetic Resistance to Onchocerca volvulus: Evidence for Linkage to Chromosome 2p from an Autosome-Wide Scan

Timmann, Christian; van der Kamp, Esther; Kleensang, André; König, Inke R.; Thye, Thorsten; Büttner, Dietrich W.; Hamelmann, Christoph; Marfo, Yeboah; Vens, Maren; Brattig, Norbert; Ziegler, Andreas; Horstmann, Rolf D.
August 2008
Journal of Infectious Diseases;8/1/2008, Vol. 198 Issue 3, p427
Academic Journal
Background. Human infections with the tissue nematode Onchocerca volvulus show strong interindividual variation in intensity, which cannot be explained by differences in exposure alone. Several lines of evidence suggest a relevant influence of human genetics. Methods. In a genome-wide search for genetic determinants of resistance, we studied 196 siblings from 51 families exposed to endemic O. volvulus transmission in the forest zone of Ghana, West Africa. The numbers of worm larvae in the skin (i.e., microfilariae), which are the established measure of O. volvulus infection intensity, were counted in 4 small skin biopsy specimens (i.e., skin snips), and the numbers of palpable subcutaneous worm nodules (i.e., onchocercomata) were assessed. Numbers were corrected for age and exposure and were analyzed for linkage to 377 autosomal microsatellite markers and additional markers in genomic regions of interest. Results. Linkage was detected between the numbers of microfilariae and chromosome 2p21-p14 (maximum multipoint log10 of odds (LOD) score of 3.80 at marker position D2S2378; empirical P = 2.9 × 10-5). Conclusions. This finding provides strong evidence that a human genetic factor influences the intensity of O. volvulus infection. The strength of the linkage signal may facilitate the identification of the decisive genetic variants.


Related Articles

  • Genome Filtering for New DNA Biomarkers of Loa loa Infection Suitable for Loop-Mediated Isothermal Amplification. Poole, Catherine B.; Ettwiller, Laurence; Tanner, Nathan A.; Jr.Evans, Thomas C.; Wanji, Samuel; Carlow, Clotilde K. S. // PLoS ONE;9/28/2015, Vol. 10 Issue 9, p1 

    Loa loa infections have emerged as a serious public health problem in patients co-infected with Onchocerca volvulus or Wuchereria bancrofti because of severe adverse neurological reactions after treatment with ivermectin. Accurate diagnostic tests are needed for careful mapping in regions where...

  • Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Mun-Gwan Hong; Pawitan, Yudi; Magnusson, Patrik K. E.; Prince, Jonathan A. // Human Genetics;Aug2009, Vol. 126 Issue 2, p289 

    A fundamental question in human genetics is the degree to which the polygenic character of complex traits derives from polymorphism in genes with similar or with dissimilar functions. The many genome-wide association studies now being performed offer an opportunity to investigate this, and...

  • In Brief.  // Nature Reviews Microbiology;May2011, Vol. 9 Issue 5, p313 

    The article offers news briefs related to microbiology. A reduction of reactive oxygen species (ROS) levels in midgut of mosquitoes was found out in a study after it takes a blood meal from haem. A 51-membered glycosylated macrolides called stambomycin A-D was identified by Laureti and...

  • Immunisation with a Multivalent, Subunit Vaccine Reduces Patent Infection in a Natural Bovine Model of Onchocerciasis during Intense Field Exposure. Makepeace, Benjamin L.; Jensen, Siv Aina; Laney, Sandra J.; Nfon, Charles K.; Njongmeta, Leo M.; Tanya, Vincent N.; Williams, Steven A.; Bianco, Albert E.; Trees, Alexander J. // PLoS Clinical Trials;Nov2009, Vol. 6 Issue 11, Special section p1 

    Human onchocerciasis, caused by the filarial nematode Onchocerca volvulus, is controlled almost exclusively by the drug ivermectin, which prevents pathology by targeting the microfilariae. However, this reliance on a single control tool has led to interest in vaccination as a potentially...

  • Human immune responses to infective stage larval-specific chitinase of filarial parasite, Onchocerca volvulus, Ov-CHI-1. Yang Wu; Egerton, Gillian; McCarthy, James S.; Nutman, Thomas B.; Bianco, Albert E. // Filaria Journal;2003, Vol. 2, p1 

    Background: Ov-CHI-1 is a chitinase specifically expressed in the infective stage larvae of the human filarial parasite Onchocerca volvulus. Evidence has show that it could be a vaccine candidate, however, there is no data available regarding the immunological status of people naturally exposed...

  • Applied field research for comprehensive helminth infection control. Soboslay, Peter T.; Gantin, Richard G.; Banla, Méba; Karabou, Potochoziou K.; Agossou, Abram; Douti, John K.; Djassoa, Gnansa; Heuschkel, Christoph; Schulz-Key, Hartwig; Hamm, David M.; Stingl, Peter // Wiener Klinische Wochenschrift;Mar2010 Supplement, Vol. 122, p27 

    The Institute for Tropical Medicine at University of Tübingen has established 30 years ago in Togo a Research Centre and Onchocerciasis Reference Laboratory (ORL). Onchocerca volvulus infection control and of other neglected tropical diseases has been the focus of activities, and those were...

  • Not every worm wrapped around a stick is a guinea worm: a case of Onchocerca volvulus mimicking Dracunculus medinensis. Mbong, Eta Ngole; Sume, Gerald Etapelong; Danbe, Flaubert; Kum, Walter Kang; Mbi, Valeri Oben; Bita Fouda, André Arsène; Atem, Peter // Parasites & Vectors;Jul2015, Vol. 8 Issue 1, p1 

    Background: Despite being certified guinea worm free in 2007, Cameroon continues surveillance efforts to ensure rapid verification of any suspected reoccurrence. This includes the investigation of every rumor and confirmation of each suspicious expulsed worm. This paper presents fieldwork...

  • Correction: A Simple Isothermal DNA Amplification Method to Screen Black Flies for Onchocerca volvulus Infection. null, null // PLoS ONE;Feb2015, Vol. 10 Issue 2, p1 

    No abstract available.

  • Human filariasis in Dass local government area of Bauchi state, Nigeria. Anosike, J. C.; Onwuliri, C. O. E.; Onwuliri, V. A. // Tropical Ecology;Winter2003, Vol. 44 Issue 2, p215 

    In Dass area of Bauchi state Northern Nigeria we studied the infection rates, intensity and clinical manifestations of human filarial infections. After an initial census, 1,638 persons who presented themselves were physically examined from a total population of 53.213. Two hundred and fifteen...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics