Differences in Age-Related Alterations in Muscle Contraction Properties in Rat Tongue and Hindlimb

Connor, Nadine P.; Ota, Fumikazu; Nagai, Hiromi; Russell, John A.; Leverson, Glen
August 2008
Journal of Speech, Language & Hearing Research;Aug2008, Vol. 51 Issue 4, p818
Academic Journal
Purpose: Because of differences in muscle architecture and biomechanics, the purpose of this study was to determine whether muscle contractile properties of rat hindlimb and tongue were differentially affected by aging. Method: Deep peroneal and hypoglossal nerves were stimulated in 6 young and 7 old Fischer 344-Brown Norway rats to allow recording of muscle contractile properties of tongue and extensor digitorum longus (EDL) muscle in the hindlimb. In the same animals, the following measurements were made: (a) twitch contraction time (CT; in milliseconds), (b) half decay time (HDT; in milliseconds), (c) maximum twitch force (in grams), (d) tetanic force, and (e) fatigue index determined from repetitive stimulation of the muscles. Results: No significant differences were observed in young versus old groups in retrusive tongue forces, whereas a significant (p < .05) decrement in EDL tetanic forces was found in old rats. Slower CT in old rats was observed only in the tongue. Old and young groups were not significantly different in fatigue index or HDT for tongue or EDL. Conclusions: Old animals generated equivalent maximum tongue forces with stimulation, but they were slower in achieving these forces than young animals. Limb and cranial muscles were not affected equally by aging. As such, information derived from limb muscle studies may not easily generalize to the cranial motor system.


Related Articles

  • The LOU/c/jall Rat as an Animal Model of Healthy Aging? Alliot, Josette; Boghossian, Stephane; Jourdan, Didier; Veyrat-Durebex, Christelle; Pickering, Gisele; Meynial-Denis, Dominique; Gaumet, Nathalie // Journals of Gerontology Series A: Biological Sciences & Medical ;Aug2002, Vol. 57 Issue 8, pB312 

    Presents a study that proposed the use of the LOU/c/jall rat as an animal model for aging research. Characteristics of the LOU/c/jall rat; Analysis of age-related changes in body weight and in food and macronutrient intakes; Examination of biological and physiological changes in the rat during...

  • On Using Model Populations to Determine Mechanical Properties of Skeletal Muscle. Application to Concentric Contraction Simulation. Sierra, M.; Miana-Mena, F.; Calvo, B.; Muñoz, M.; Rodríguez, J.; Grasa, J. // Annals of Biomedical Engineering;Oct2015, Vol. 43 Issue 10, p2444 

    In the field of computational biomechanics, the experimental evaluation of the material properties is crucial for the development of computational models that closely reproduce real organ systems. When simulations of muscle tissue are concerned, stress/strain relations for both passive and...

  • Effect of Contraction History on Torque Deficits by Stretches of Active Rat Skeletal Muscles. Willems, Mark E.T.; Stauber, William T. // Canadian Journal of Applied Physiology;Aug2002, Vol. 27 Issue 4, p323 

    Effects of contraction history on torque deficits by stretches of active skeletal muscles were examined. After three contractions using maximal and submaximal activation (80 and 20 Hz) at an ankle position of 40° (i.e., long muscle length) and with maximal activation at 120° (i.e., short...

  • Adaptive stretch-shortening contractions: diminished regenerative capacity with aging. Baker, Brent A.; Hollander, Melinda S.; Mercer, Robert R.; Kashon, Michael L.; Cutlip, Robert G. // Applied Physiology, Nutrition & Metabolism;Dec2008, Vol. 33 Issue 6, p1181 

    This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in...

  • Effects of glutathione depletion and age on skeletal muscle performance and morphology following chronic stretch-shortening contraction exposure. Baker, Brent A.; Hollander, Melinda S.; Kashon, Michael L.; Cutlip, Robert G. // European Journal of Applied Physiology;Feb2010, Vol. 108 Issue 3, p619 

    The involvement of glutathione in the response of skeletal muscle following repetitive, high-intensity mechanical loading is not known. We examined the influence of a glutathione antagonist [ l-Buthionine Sulfoximine (BSO)] had on the adaptability of skeletal muscle during chronic mechanical...

  • Characteristics of Tetanic Force Produced by the Sternomastoid Muscle of the Rat. Sobotka, Stanislaw; Liancai Mu // Journal of Biomedicine & Biotechnology;2010, p1 

    The sternomastoid (SM) muscle plays an important role in supporting breathing. It also has unique anatomical advantages that allow its wide use in head and neck tissue reconstruction and muscle reinnervation. However, little is known about its contractile properties. The experiments were run on...

  • The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus. Yu-Cheng Lu; Hwei-Hsien Chen; Chien-Hsin Ko; Yi-Ruu Lin; Ming-Huan Chan // Naunyn-Schmiedeberg's Archives of Pharmacology;Oct2003, Vol. 368 Issue 4, p262 

    The effects of honokiol and magnolol extracted from the Magnolia officinalis on muscular contractile responses and intracellular Ca2+ mobilization were investigated in the non-pregnant rat uterus. Honokiol and magnolol (1–100 μmol/l) were observed to inhibit spontaneous and uterotonic...

  • The effects of dietary-induced obesity on the biomechanical properties of femora in male rats. Brahmabhatt, V; Rho, J; Bernardis, L; Gillespie, R; Ziv, I // International Journal of Obesity & Related Metabolic Disorders;Aug1998, Vol. 22 Issue 8, p813 

    OBJECTIVE: To assess the effects of diet-induced obesity (DIO), on the biomechanical and biochemical properties of the femur in mature male rats. DESIGN AND SUBJECTS: Two groups of male rats were studied. The DIO experimental group was fed a high caloric diet and a 31% sucrose solution as...

  • Effect of Terminalia chebula on oxidative stress in the liver of young and aged rats. Mahesh, R.; Begum, V. Hazeena // Indian Journal of Gerontology;2007, Vol. 21 Issue 3, p244 

    The article presents a study which examined how Terminalia chebula extract affects the oxidative stress in the liver of young and old rats. The study found that after giving a dose of Terminalia chebula, the level of free radicals in rats returned to normal. It also showed that Terminalia...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics