TITLE

Effect of Acarbose on Vascular Disease in Patients with Abnormal Glucose Tolerance

AUTHOR(S)
Markolf Hanefeld; Frank Schaper; Carsta Koehler
PUB. DATE
June 2008
SOURCE
Cardiovascular Drugs & Therapy;Jun2008, Vol. 22 Issue 3, p225
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract Introduction  Excessive postprandial (pp) glucose excursion in people with IGT and type 2 diabetes is associated with a cascade of proatherogenic events. Acarbose, a potent competitive inhibitor of α-glucosidases of the small intestine specifically reduces pp hyperglycemia with an average reduction of HbA1c by 0.8% in Cochrane metaanalysis. This is associated with pleiotropic effects on a broad spectrum of cardiovascular (CV) risk factors: reduction of overweight, lowering of blood pressure, triglycerides, hsCRP, fibrinogen and other biomarkers of low grade inflammation. Results and discussion  Flow mediated vasodilation was improved and progression of intima media thickness was reduced by acarbose. In the STOP-NIDDM trial in people with IGT acarbose decreased the incidence of diabetes by 36%. The STOP-NIDDM trial with CV events as secondary objective is the only intervention trial in people with IGT so far with a significant benefit for CV disease inclusive hypertension. In a metaanalysis of controlled studies (MeRIA) in patients with type 2 diabetes, treatment with acarbose was associated with a 64% lower rate of myocardial infarction and 35% less CV events. Conclusion  Thus results so far available prove that acarbose is an effective and safe drug to treat abnormal glucose tolerance. They suggest that acarbose can help to control a broad spectrum of CV risk factors and may prevent CV disease.
ACCESSION #
33329289

 

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