Anxiolytic Activity Of Seed Extract Of Caesalpinia Bonducella (Roxb) In Laboratory Animals

Ali, Altaf; Rao, N. Venkat; Shalam, Md.; Gouda, T. Shivaraj; Babu, Jeevan Mane; Shantakumar, S. M.
July 2008
Internet Journal of Pharmacology;2008, Vol. 5 Issue 2, p13
Academic Journal
In the traditional system of Indian medicine C.bonducella is widely used for its antipyretic, antiperiodic, anticonvulsant and antiparalytic activities. The present study was aimed to explore the anxiolytic activities of seed extract of C.bonducella in experimental animals, mice and rats. In Stair-case model, all the three doses i-e low, medium and high 400, 600 and 800mg/kg of PECB had showed a significant and dose dependent Anxiolytic activity by increasing the number of steps climbed, without any significant effect on rearings by all these three doses. Similarly in EPM model medium and high doses, but not the low dose of PECB had significantly enhanced both number of entries and time spent in open arms and decreased in number of entries and time spent in closed arms. In Hole- board model, medium and high doses 600 and 800mg/kg but not the low dose 400mg/kg of PECB had significantly enhanced the number, latency and the duration of head dipping but not the rearings. However in LDT model high doses 800mg/kg of PECB had significantly exhibited anxiolytic activity by increasing time spent, number of crossings in light compartment and decreased the time spent in dark compartment and decreased the number of rearings in both light and dark compartments. In OFT models, medium and high doses 600 and 800mg/kg but not the low dose 400mg/kg of PECB had significantly enhanced total locomotion, central locomotion, number of grooming but the immobility time has drastically reduced. All doses of PECB have not exerted any significant effect with rearing, defecation and urination. Moreover in Mirror-chamber model of anxiety, both medium and high doses 600 and 800mg/kg but not the low dose 400mg/kg of PECB had significantly reduced the time latency to enter in to the mirror chamber and increased the number of entries and time spent in the chamber. Thus the result recorded with above experimental models confirms the anxiolytic activity of PECB.


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