Costa, Militino; Silva, Marilia Barreto Gameiro; Silva, José Antonio; Skare, Thelma L.
April 2008
Acta Reumatológica Portuguesa;2008, Vol. 33 Issue 2, p173
Academic Journal
Background: Children born from mothers with anti-Ro, La or RNP autoantibodies may develop neonatal lupus. One of the manifestations of neonatal lupus is congenital atrio ventricular block. Objective: To study EKG PR interval in adult systemic lupus erythematosus (SLE) patients with anti- -Ro, anti-La and anti-RNP autoantibodies. Methods: PR intervals and the presence of anti-Ro, La and RNP antibodies were studied in 61 SLE patients and compared with 61 controls. Results: 36.6% of SLE patients were anti-Ro positive, 20% were anti-La and 22.9% were anti-RNP positive. All studied PR intervals were within normal limits (upper limit of 0.2 sec). We did not find any association between PR interval length and the presence of anti-Ro (p=0.54), anti-La (p=0.45) or anti- -RNP autoantibodies (p=0.36). Conclusion: The presence of anti-Ro, La and RNP autoantibodies does not influence PR interval in adult SLE patients.


Related Articles

  • Biosensor analyses of serum autoantibodies: application to antiphospholipid syndrome and systemic lupus erythematosus. Thaler, Markus; Buhl, Alexander; Welter, Harald; Schreiegg, Anita; Kehrel, Marcus; Alber, Bettina; Metzger, Jochen; Luppa, Peter B. // Analytical & Bioanalytical Chemistry;Mar2009, Vol. 393 Issue 5, p1417 

    Autoimmune disorders are rare human diseases characterized by the presence of circulating autoantibodies that bind the body’s own structural compounds as target antigens. The detection of autoantibodies is important for the diagnostic process. Immunofluorescence and immunoassay methods do...

  • LJP 1082: a toleragen for Hughes syndrome. Merrill, J.T. // Lupus;2004, Vol. 13 Issue 5, p335 

    A hallmark of systemic lupus erythematosus (SLE) and related autoimmune diseases such as the antiphospholipid syndrome (APL or Hughes syndrome) is an apparent breakdown in tolerance, the process by which the body distinguishes self from nonself in order to maintain a versatile immune defense...

  • Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia. Nolsøe, R. L.; Kelly, J. A.; Pociot, F.; Moser, K. L.; Kristiansen, O. P.; Mandrup-Poulsen, T.; Harley, J. B. // Genes & Immunity;Dec2005, Vol. 6 Issue 8, p699 

    Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens and tissue injury. Defective apoptosis of activated immune cells leads to the development of autoantibodies in SLE. FasL initiated apoptosis is central for...

  • Lessons for lupus from tumour necrosis factor blockade. De Bandt, M. // Lupus;2006, Vol. 15 Issue 11, p762 

    Systemic lupus erythematosus (SLE) is a systemic non-organ specific autoimmune disease associated with multiple autoantibodies targeting autoantigens from the nucleus. Given the complex pathophysiology of SLE and the role of TNF alpha in that disease, modulation of TNF alpha (in SLE or non-SLE...

  • Plasminogen activator inhibitor-1 polymorphisms (−844 G>A and HindIII C>G) in systemic lupus erythematosus: association with clinical variables. Padilla-Gutiérrez, Jorge; Palafox-Sánchez, Claudia; Valle, Yeminia; Orozco-Barocio, Gerardo; Oregón-Romero, Edith; Vázquez-Del Mercado, Mónica; Rangel-Villalobos, Héctor; Llamas-Covarrubias, Mara; Muñoz-Valle, José // Clinical & Experimental Medicine;Mar2011, Vol. 11 Issue 1, p11 

    Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the presence of autoantibodies against nuclear autoantigens as well as cytoplasmic and circulating proteins. Recent studies have demonstrated mechanisms responsible for modulation of the immune response by the...

  • Predominance of IgG1 and IgG3 subclasses of autoantibodies to neutrophil cytoplasmic antigens in patients with systemic lupus erythematosus. Manolova, I.; Dancheva, M.; Halacheva, K. // Rheumatology International;Apr2002, Vol. 21 Issue 6, p227 

    The IgG subclasses displayed by antibodies to four neutrophil cytoplasmic antigens were studied in 20 patients with systemic lupus erythematosus (SLE) by solid-phase enzyme immunoassays and monoclonal antibodies to human IgG subclasses. The IgG subclass reactivity of antineutrophil cytoplasmic...

  • Taming lupus-a new understanding of pathogenesis is leading to clinical advances. Liu, Zheng; Davidson, Anne // Nature Medicine;Jun2012, Vol. 18 Issue 6, p871 

    Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and damage to multiple organ systems. Over the years, patients with SLE have been managed largely with empiric...

  • BAFF-ling autoantibodies. Sarantopoulos, Stefanie; Maureen A. Su // Journal of Clinical Investigation;Dec2013, Vol. 123 Issue 12, p5006 

    There is emerging evidence that autoantibodies directed against cytokines modulate the severity of autoimmune disease. Identification of cytokine-targeted autoantibodies in patients can be informative for diagnosis and predicting clinical outcome. In this issue of the JCI, Price and colleagues...

  • Association of Increased Frequencies of HLA-DPB1*05:01 with the Presence of Anti-Ro/SS-A and Anti-La/SS-B Antibodies in Japanese Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients. Furukawa, Hiroshi; Oka, Shomi; Shimada, Kota; Sugii, Shoji; Hashimoto, Atsushi; Komiya, Akiko; Fukui, Naoshi; Nagai, Tatsuo; Hirohata, Shunsei; Setoguchi, Keigo; Okamoto, Akira; Chiba, Taiichiro; Suematsu, Eiichi; Miyashita, Taiichiro; Migita, Kiyoshi; Suda, Akiko; Nagaoka, Shouhei; Tsuchiya, Naoyuki; Tohma, Shigeto // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Introduction: Autoantibodies to ribonucleoprotein are associated with a variety of autoimmune diseases, including rheumatoid arthritis (RA). Many studies on associations between human leukocyte antigen (HLA) alleles and RA have been reported, but few have been validated in RA subpopulations with...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics