Antithrombotic efficacy and excess bleeding: a fine balance

Rao, A. Koneti
June 2008
Cardiology Today;Jun2008, Vol. 11 Issue 6, p31
The article discusses the effects of using adenosine diphosphate (ADP) P2Y 12 antagonist agent prasugrel in patients with acute coronary syndromes as shown in a trial. Compared to clopidogrel, the prasugrel consistently and largely inhibits ADP, decreases primary endpoint that causes deaths, and decreases rates of myocardial infarction (MI). Despite these results, the prasugrel increases bleeding events in the prasugrel group. It also discusses several risks associated with excess bleeding.


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