TITLE

Guidelines for the diagnosis and treatment of acromegaly: a Canadian perspective

AUTHOR(S)
Patel, Yogesh C.; Ezzat, Shereen; Chik, Constance L.; Rorstad, Otto P.; Serri, Omar; Ur, Ehud; Wilkins, G. Edward
PUB. DATE
June 2000
SOURCE
Clinical & Investigative Medicine;Jun2000, Vol. 23 Issue 3, p172
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Acromegaly is a chronic, debilitating condition caused by excessive secretion of growth hormone (GH). In the majority of cases the condition results from benign pituitary adenomas or, rarely, from ectopic production of GH-releasing hormone. Regardless of the cause, excess GH results in physical disfigurement associated with arthropathy, diabetes, hypertension, cardiac dysfunction, obstructive sleep apnea and colonic neoplasia. The death rate for acromegalic patients is 2 to 3 times higher than that of the general population, but with appropriate reduction of GH hypersecretion it tends to shift into the normal range. Treatment is thus aimed at normalizing GH secretion, eradicating or stabilizing the pituitary tumour while preserving normal pituitary function, and managing the associated complications. The treatment modalities available to achieve these objectives include transsphenoidal surgery, pharmacotherapy and radiation, or various combinations of these. This review provides an update on our current understanding of the pathophysiology of GH hypersecretion in acromegaly, the newly defined diagnostic criteria and the end point for a cure for acromegaly, and on new developments in drug treatment with the advent of slow-release forms of somatostatin analogues and the longer-acting dopamine receptor agonists, as well as in the area of radiotherapy. Its main purpose is to guide any physician involved in the diagnosis and management of patients with acromegaly.
ACCESSION #
3310951

 

Related Articles

  • BOX 10-1 DISORDERS OF GROWTH HORMONE. Scanlon, Valerie C.; Sanders, Tina // Essentials of Anatomy & Physiology;Jan2007, p230 

    Information on disorders of growth hormone from Chapter 10 of the book "Essentials of Anatomy & Physiology" is presented. It identifies the cause of pituitary dwarfism, gigantism and acromegaly. It reveals how pituitary dwarfism nay be reversed. It describes the physiological effects of...

  • Hyperhidrosis in acromegaly: effectiveness of topical aluminum chloride hexahydrate solution.  // British Medical Journal;10/13/1979, Vol. 2 Issue 6195, p901 

    Examines the use of topical aluminum chloride hexahydrate solution to treat acromegalic patients with hyperhidrosis. Association of sweating with excessive secretion of growth hormone; Removal of pituitary tumors; Clinical features of patients with acromegaly.

  • Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion. Lim, Michael J.; Barkan, Ariel L.; Buda, Andrew J.; Lim, M J; Barkan, A L; Buda, A J // Annals of Internal Medicine;11/1/92, Vol. 117 Issue 9, p719 

    Objective: To examine the possible role of growth hormone as a pathogenetic factor in the development of myocardial hypertrophy in acromegaly.Design: An uncontrolled clinical trial.Setting: Tertiary-care medical center.Patients: Sixteen...

  • acromegaly.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p34 

    An encyclopedia entry for "acromegaly," which is a syndrome of excessive secretion of growth hormone, is presented.

  • Acromegaly with Normal Fasting Growth Hormone Concentrations but Abnormal Growth Hormone Regulation. Mims, Robert B.; Bethune, John E. // Annals of Internal Medicine;Dec74, Vol. 81 Issue 6, p781 

    Focuses on a study which evaluated growth hormone dynamics in patients with acromegaly. Clinical and laboratory features of acromegalic patients; Materials and methods used for the study; Findings.

  • Exon-3 deleted GH receptor linked to long-term complications of acromegaly.  // Endocrine Today;Nov2009, Vol. 7 Issue 13, p33 

    This article discusses a study on the prevalence of irreversible comorbidities in patients with long-term disease control of acromegaly and deletion of exon 3 of the growth hormone receptor (d3GHR).

  • Treatment of Acromegaly. Utiger, Robert D. // New England Journal of Medicine;04/20/2000, Vol. 342 Issue 16, p1210 

    Editorial. Discusses acromegaly, which results from the hypersecretion of growth hormone. Effectiveness of treatment by transsphenoidal surgery; Further nonsurgical treatment options if surgery is not effective; Efficacy and side effects of the growth hormone blocker pegvisomant; Need for...

  • Body Image Disturbance in Acromegaly Patients Compared to Nonfunctioning Pituitary Adenoma Patients and Controls. Conaglen, Helen M.; de Jong, Dennis; Crawford, Veronica; Elston, Marianne S.; Conaglen, John V. // International Journal of Endocrinology;5/20/2015, Vol. 2015, p1 

    Purpose. Excess growth hormone secretion in adults results in acromegaly, a condition in which multiple physical changes occur including bony and soft tissue overgrowth. Over time these changes can markedly alter a person’s appearance. The aim of this study was to compare body image...

  • Acromegaly: treatment after 100 years. Wass, J.A.H. // BMJ: British Medical Journal (International Edition);12/11/93, Vol. 307 Issue 6918, p1505 

    Comments on the treatment of acromegaly. Increase in the morbidity and mortality among patients with acromegaly; Aims of the treatment; Concentration of growth hormones.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics