Ehlers-Danlos syndrome and multiple sclerosis: a possible association

Vilisaar, J.; Harikrishnan, S.; Suri, M.; Constantinescu, C. S.
May 2008
Multiple Sclerosis (13524585);May2008, Vol. 14 Issue 4, p567
Academic Journal
Ehlers-Danlos syndrome (EDS) has various neurological manifestations. Here we present an association of EDS with multiple sclerosis (MS). Four MS patients from a total of 1892 followed up at our MS outpatient clinics had EDS. This frequency suggests 10-11 times increased prevalence of EDS in MS patients compared with the general population (P = 0.02). Suggested implications include a possible causal relationship on a connective tissue level with a higher susceptibility to MS in EDS. Diagnostic and management considerations are important in coexisting MS and EDS. Our patients had relatively florid lesions on brain MRIs and typical course and features of MS.


Related Articles

  • A life-threatening complication of Ehlers-Danlos syndrome. Behjati, Sam; Knight, Yolande; Goebells, Archana; Borgstein, Rudi; Myint, Fiona // British Journal of Hospital Medicine (17508460);Jun2009, Vol. 70 Issue 6, p360 

    The article presents a case study of a 26-year-old young Pakistani man with Ehlers-Danlos syndrome who was admitted due to sudden onset left lover abdominal pain and constipation. Based on computed tomography angiogram result, the patient had hematoma at the left pelvis. He was undergone an...

  • Ascorbate Action on Normal and Mutant Human Lysyl Hydroxylases from Cultured Dermal Fibroblasts. Miller, Robert L.; Elsas, Louis J.; Priest, Robert E. // Journal of Investigative Dermatology;May79, Vol. 72 Issue 5, p241 

    The mechanism of ascorbate action on lysyl hydroxylase (LH) was investigated using cultured dermal fibroblasts from a patient with hydroxylysine-deficient collagen disease and from appropriate control patients. Cells from this patient had moderately impaired LH and both parents had intermediate...

  • A Recessive Form of the Ehlers—Danlos Syndrome Caused by Tenascin-X Deficiency. Schalkwijk, Joost; Zweers, Manon C.; Steijlen, Peter M.; Dean, Willow B.; Taylor, Glen; van Vlijmen, Ivonne M.; van Haren, Brigitte; Miller, Walter L.; Bristow, James // New England Journal of Medicine;10/18/2001, Vol. 345 Issue 16, p1167 

    Background: The Ehlers–Danlos syndrome is a heritable connective-tissue disorder caused by defects in fibrillar-collagen metabolism. Mutations in the type V collagen genes account for up to 50 percent of cases of classic Ehlers–Danlos syndrome, but many other cases are unexplained....

  • Ehlers-Danlos Syndrome (EDS) type IV. Review of the literature. Macabu Badauy, Cristiano; Gomes, Sabrina S.; Sant'Ana Filho, Manoel; Bogo Chies, José Artur // Clinical Oral Investigations;Sep2007, Vol. 11 Issue 3, p183 

    Ehlers-Danlos syndrome (EDS) is a heterogeneous group of connective tissue heritable disorders. EDS type IV is a rare form that presents typical clinical signs, such as easy bruising and haematomas at sites of trauma, skin manifestations (translucent skin with visible veins), and joint...

  • Ehlers-Danlos syndrome type IV and recurrent carotid-cavernous fistula: review of the literature, endovascular approach, technique and difficulties. Desal, H. A.; Toulgoat, F.; Raoul, S.; Guillon, B.; Bommard, S.; Naudou-Giron, E.; Auffray-Calvier, E.; de Kersaint-Gilly, A. // Neuroradiology;Apr2005, Vol. 47 Issue 4, p300 

    We report the follow-up of a previously published case (Forlodou et al. Neuroradiology 38:595-597, 1996) of carotido-cavernous fistulas (CCFs) in a patient presenting with type IV Ehlers-Danlos syndrome (EDS 4) that were successfully treated twice by an endovascular approach. Initial treatment...

  • Ehlers-Danlos syndrome type IV. Germain, Dominique P. // Orphanet Journal of Rare Diseases;2007, Vol. 2, p32 

    Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy...

  • The Vascular Type of Ehlers-Danlos Syndrome. Watanabe, Atsushi; Shimada, Takashi // Journal of Nippon Medical School;2008, Vol. 75 Issue 5, p254 

    Vascular type of Ehlers-Danlos syndrome (EDS), also known as EDS type IV (NIM#130050) is a life-threatening autosomal dominant inherited disorder of connective tissue, caused by mutations of the COL3A1 gene. Vascular EDS causes severe fragility of connective tissues with arterial and intestinal...

  • A large abdominal intercostal hernia in a patient with vascular type Ehlers-Danlos syndrome: a surgical challenge. Weerd, L.; Kjæve, J.; Gurgia, L.; Weum, S. // Hernia;Feb2012, Vol. 16 Issue 1, p117 

    A patient with vascular type Ehlers-Danlos syndrome developed a large abdominal intercostal hernia secondary to coughing. The tissue friability and associated risks for arterial ruptures and visceral perforations in these patients make hernia repair challenging. The hernia was successfully...

  • Zespół genetyczny sugerujÄ…cy naczyniowy fenotyp Zespół Ehlersa-Danlosa u 14-letniego chÅ‚opca z dominujÄ…cymi objawami pozapiramidowymi we wczesnym dzieciÅ„stwie i z zaburzeniami wzrastania. Górska, Anna; Szczepański, Wojciech; Urban, Mirosława; Marcinowicz, Ludmiła // Pediatric Endocrinology, Diabetes & Metabolism;2008, Vol. 14 Issue 3, p199 

    Introduction: The Ehlers-Danlos Syndrome (EDS) is a heterogeneous group of rare genetic disorders with various clinical features, which result from faulty collagen structure or disturbances in collagen synthesis. The case study: The Ehlers-Danlos Syndrome was diagnosed in patient at the age of 7...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics