TITLE

Association of hyperhomocysteinemia and Chlamydia pneumoniae infection with carotid atherosclerosis and coronary artery disease in Japanese patients

AUTHOR(S)
Yasunori Sawayama; Masafumi Tatsukawa; Shinji Maeda; Hachiro Ohnishi; Norihiro Furusyo; Jun Hayashi
PUB. DATE
June 2008
SOURCE
Journal of Infection & Chemotherapy (Springer Science & Business;Jun2008, Vol. 14 Issue 3, p232
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  An elevated plasma level of homocysteine (Hcy) and infection by Chlamydia pneumoniae (C. pneumoniae) have been suggested as independent risk factors for carotid atherosclerosis (CA) and coronary artery disease (CAD), but the mechanisms involved are unclear. We investigated the correlation between positivity for antibody to C. pneumonia (anti-C. pneumoniae) and the Hcy level in patients with CA and CAD. The total plasma homocysteine (tHcy) concentration was determined in 99 patients with CA and 31 patients with CAD, as well as 119 controls with matched risk factors for atherosclerosis. The tHcy level was measured with a Bio-Rad microplate enzyme immunoassay. In the CAD group, the tHcy level (13.67 μmol/l) was significantly higher than that in other groups (CA group, 10.96 μmol/l; control group, 9.95 μmol/l; ANOVA, P = 0.0006). Positivity for anti-C. pneumoniae IgG was significantly more common in the CAD group (77.4%) than in the other groups (CA group, 53.5%; control group, 54.6%; ANOVA, P = 0.0490). There was no association between anti-C. pneumoniae IgA positivity or tHcy and conventional risk factors. However, anti-C. pneumoniae IgG positivity was significantly more common in subjects with higher tHcy levels than in those with low tHcy levels from each of the 3 groups. The CAD group had significantly higher tHcy levels, and tHcy was significantly associated with anti-C. pneumoniae IgG positivity. These findings indicate that elevation of tHcy is related to positivity for anti-C. pneumoniae IgG in patients with CAD.
ACCESSION #
33055426

 

Related Articles

  • Interrelationship of interleukin 6, C-reactive protein and Chlamydia pneumoniae IgG antibodies in patients with acute coronary syndromes. Burazor, Ivana; Vojdani, Aristo; Burazor, Mirko // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Jun2008, Vol. 65 Issue 6, p425 

    Background/Aim. Inflammation due to infection could be associated with the development of acute coronary syndromes, clinical manifestations of ongoing atherosclerosis in vessel walls. Our aim was determine whether interleukin 6, C-reactive protein and Chlamydia pneumoniae IgG antibodies are...

  • Presence of Chlamydia pneumoniae in patients with and without atherosclerosis. Podsiadły, E.; Przyłuski, J.; Kwiatkowski, A.; Kruk, M.; Wszoła, M.; Nosek, R.; Rowiński, W.; Rużyłło, W.; Tylewska-Wierzbanowska, S. // European Journal of Clinical Microbiology & Infectious Diseases;Aug2005, Vol. 24 Issue 8, p507 

    Data published over the past decade show that Chlamydia pneumoniae is likely associated with the development of atherosclerosis. The aim of this study was to ascertain whether C. pneumoniae infections occur more frequently in patients with atherosclerosis than in healthy subjects. A total of 517...

  • Detection of Chlamydia pneumoniae within Peripheral Blood Monocytes of Patients with Unstable Angina or Myocardial Infarction. Maass, Matthias; Jahn, Jurgen; Gieffers, Jens; Dalhoff, Klaus; Katus, Hugo A.; Solbach, Werner // Journal of Infectious Diseases;6/15/2000 Supplement 3, Vol. 181, pS449 

    Presents a study that uses polymerase chain reaction detection of chlamydial DNA applied to cells from patients with angiographically identified unstable angina or acute myocardial infarction. Presence of Chlamydia pneumoniae in monocytes/macrophages of a significant proportion of persons with...

  • Detection of Chlamydophila pneumoniae (Chlamydia pneumoniae) in endarteroctomy specimens of coronary heart diseases patients. Satpathy, Gita; Bhan, Anil; Sharma, Anjana; Kar, U. K. // Indian Journal of Medical Research;Nov2008, Vol. 128 Issue 5, p658 

    Background & objectives: Association of Chlamydia pneumoniae with atherosclerosis and coronary artery disease is debated. Increased antibody levels against C. pneumoniae in patients with coronary artery disease is widely reported. Direct evidence would be demonstration of C. pneumoniae, its...

  • Seroprevalence of Chlamydia pneumoniae Antibodies in a Young Adult Population Sample Living in Verona. Ferrari, M.; Poli, A.; Olivieri, M.; Tardivo, S.; Biasin, C.; Balestreri, F.; dal Molin, G.; Lo Cascio, V.; Campello, C. // Infection;Feb2000, Vol. 28 Issue 1, p38 

    The aim of the study was to evaluate the prevalence of antibodies to Chlamydia pneumoniae in a random population sample of 369 young adults (aged 20-44 years), living in Verona, Italy. lgG and IgM titers were measured by micro-immunofluorescence. lgG antibodies, greater or equal to 16,were found...

  • Association of stress derived risk factors, Chlamydia pneumoniae and high sensitive C-reactive protein in Coronary Artery Disease patients. Jha, Hem C.; Vidya, Aabha; Prasad, Jagdish; Mittal, Aruna // Internet Journal of Cardiology;2009, Vol. 7 Issue 1, p2 

    Background:Atherosclerosis is a chronic inflammatory disease and has a multifactorial etiology. There is growing evidence that Chlamydia pneumoniae (C. pneumoniae) may be involved in the pathogenesis of atherosclerosis. In India higher incidence of persistence chronic infection of C. pneumoniae...

  • Chlamydia pneumoniae and Coronary Artery Disease: The Antibiotic Trials. Higgins, John P. // Mayo Clinic Proceedings;Mar2003, Vol. 78 Issue 3, p321 

    Discusses the potential role of Chlamydia pneumoniae infection in atherosclerosis. Randomized clinical trials of antichlamydial antibiotics in patients with coronary heart disease; Detection of infection; Four classes of antibiotics against infection; Specific factors that may link Chlamydia...

  • Chlamydia pneumoniae in Atherosclerotic Tissue. Taylor-Robinson, D.; Thomas, B. J. // Journal of Infectious Diseases;6/15/2000 Supplement 3, Vol. 181, pS437 

    Discusses the presence of Chlamydia pneumoniae organisms within foam and smooth muscle cells of atherosclerotic plaques and their role in atherosclerosis. Association between C. pneumoniae and coronary artery disease based on serologic studies; Evidence of C. pneumoniae in atherosclerotic...

  • Mouse Models of C. pneumoniae Infection and Atherosclerosis. Campbell, Lee Ann; Blessing, Erwin; Rosenfeld, Michael; Tsun-mei Lin; Cho-chou Kuo // Journal of Infectious Diseases;6/15/2000 Supplement 3, Vol. 181, pS508 

    Presents studies using mouse models to determine whether Chlamydia pneumoniae establishes chronic infection of the aorta and contributes to atherogenesis. Strains of mice used in the study; Pathogenesis of C. pneumoniae respiratory tract infection; Ability of C. pneumoniae to induce the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics