TITLE

Is rapid preparation for thyroidectomy in severe Graves’ disease beneficial? The relationship between clinical and immunohistochemical aspects

AUTHOR(S)
Iyad Hassan; Radu Danila; Heisam Aljabri; Sebastian Hoffmann; Annette Wunderlich; Elias Karakas; Andreas Zielke
PUB. DATE
April 2008
SOURCE
Endocrine (1355008X);Apr2008, Vol. 33 Issue 2, p189
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract   Background To evaluate the effect of Lugol’s Iodine (LI) on angiogenic characteristics and postthyroidectomy morbidity in patients with Graves’ Disease (GD). Methods Medical records of 153 patients, who underwent thyroidectomies for GD between 1987 and 2006 were reviewed. LI in addition to antithyroid drugs (ATD) was administered to 16 toxic Graves’ cases (group I), while 137 received ATD only (group II). In order to evaluate thyroid vascularity, immunohistochemical staining (IHS) for VEGF and CD31 for assessing microvessel density (MVD) were performed in group I, 20 random cases of group II, and 7 stochastic patients with non-toxic goiter (group III). Results Early postoperative complications were significantly higher in group I compared to group II: (transient recurrent nerve palsy (P P P P Conclusion Preoperative LI treatment may be associated with increased early postoperative morbidity and did not affect thyroid vascularity.
ACCESSION #
33049334

 

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