Androgen receptor gene CAGn trinucleotide repeats polymorphism in Chinese women with polycystic ovary syndrome

Jie Hong; Yifei Zhang; Weiqiong Gu; Zhenni Chi; Yuxia Su
April 2008
Endocrine (1355008X);Apr2008, Vol. 33 Issue 2, p165
Academic Journal
Abstract  Trinucleotide repeats CAGn in androgen receptor gene is thought to be a potential site of genetic susceptibility to polycystic ovary syndrome (PCOS). However, previous studies of PCOS have shown variable association of CAGn polymorphism with PCOS. In order to evaluate CAGn polymorphism in Chinese women with PCOS, we have genotyped CAGn repeat numbers in female Chinese subjects (148 PCOS patients and 104 control subjects). The mean CAGn repeat lengths of PCOS patients and control subjects were similar (22.88 ± 1.76 vs. 22.85 ± 1.60; P = NS). No difference in the mean CAGn repeat lengths of hyperandrogenic and nonhyperandrogenic subgroups of PCOS patients was found (22.86 ± 1.68 vs. 22.91 ± 1.84; P = NS). Moreover, no difference was found in the term of mean CAGn repeat lengths in the nonhyperandrogenic subgroup and the control subjects (22.86 ± 1.68 vs. 22.85 ± 1.60; P = NS). However, mean CAGn repeat lengths were negatively correlated with serum total cholesterol and low-density lipoprotein-cholesterol concentration in PCOS patients (r = –0.182, P r = –0.210, P n repeat length polymorphism may not be a major determinant of PCOS, but it may influence the lipid metabolism of PCOS patients.


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