TITLE

Inhibition of rat granulosa cell differentiation by overexpression of Gαq

AUTHOR(S)
Rosalba Escamilla-Hernandez; Lynda Little-Ihrig; Anthony Zeleznik
PUB. DATE
April 2008
SOURCE
Endocrine (1355008X);Apr2008, Vol. 33 Issue 1, p21
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Activation of FSH and LH receptors in undifferentiated granulosa cells (i.e., no prior exposure to FSH) results in comparable induction of progesterone production, but activation of the LH receptor is less effective than FSH in inducing aromatase and the native LH receptor. Because the LH receptor can also activate the Gαq signaling pathway, we investigated whether activation of this pathway could be responsible for these differences. Overexpression of Gαq inhibited FSH induction of both the estradiol and progesterone biosynthetic pathways as well as mRNA levels for cholesterol side-chain cleavage enzyme (P450scc), 3β-hydroxysteroid dehydrogenase (3β-HSD), LH receptor (LHr), and P450aromatase (aromatase). This suppression was associated with a reduction (P P 
ACCESSION #
32951296

 

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