Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women

La-or Chailurkit; Suwannee Chanprasertyothin; Wallaya Jongjaroenprasert; Boonsong Ongphiphadhanakul
April 2008
Endocrine (1355008X);Apr2008, Vol. 33 Issue 1, p84
Academic Journal
Abstract  Although adiponectin levels are associated with obesity and insulin insensitivity, the role of adiponectin in the progression to diabetes in non-obese subjects is unclear. Therefore, 289 women aged 50–80 years without previous history of diabetes or impaired glucose tolerance (IGT) were studied. They were classified as normal glucose tolerance (NGT), IGT or diabetes based on WHO criteria. Insulin sensitivity (S) and beta cell function (B) indices were calculated using homeostasis model assessment (HOMA). In obese women with BMI ≥ 25 kg/m2 (n = 161), there were declines in HOMA-%S (P P P 2 (n = 128), there was no significant change in HOMA-%S in women with IGT and diabetes as compared to women with NGT. However, HOMA-%B (P P 


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