TITLE

Clinical features of adverse reactions associated with telbivudine

AUTHOR(S)
Xue-Song Zhang; Rui Jin; Shi-Bin Zhang; Ming-Ling Tao; Larrubia, Juan Ramón; Lai, Vincent
PUB. DATE
June 2008
SOURCE
World Journal of Gastroenterology;6/14/2008, Vol. 14 Issue 22, p3549
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
AIM: To analyze the clinical features and risk factors of adverse reactions associated with telbivudine. METHODS: Clinical data were collected from cases that presented with serious adverse reactions to telbivudine. We analyzed general information and medicine status, clinical features, results of examination, and misdiagnosis. RESULTS: Out of 105 patients who were treated with telbivudine for hepatitis B in an outpatient department from January, 2007 to January, 2008, five presented with serious adverse drug reactions. Most of these five patients had used other nucleoside analogues in the past. Four were treated with a combination of telbivudine and interferon or another nucleoside analogue, while the other received an increased dose of telbivudine. The main adverse reactions were myalgia and general weakness. This was accompanied by cardiac arrhythmia in one patient, and nervous symptoms in three. Serum creatine kinase was elevated. The rate of misdiagnosis was high. CONCLUSION: The adverse reactions were related to telbivudine, but the biological mechanism of the reactions is not yet clear. Combination therapy with interferon or another nucleoside analogue and a high dose may increase the risk of adverse reactions.
ACCESSION #
32920877

 

Related Articles

  • Telbivudine. Levien, Terri; Baker, Danial E. // Hospital Pharmacy;Apr2007, Vol. 42 Issue 4, p345 

    The article offers information on Telbivudine, a thymidine nucleoside analog antiviral agent. This drug is used for treating chronic hepatitis B in patients experiencing viral replication and persistent elevations in serum aminotransferases. Telbivudine is administered orally and once daily in...

  • Preface. Kukhanova, Marina // Current Pharmaceutical Design;Mar2000, Vol. 6 Issue 5, p1l 

    Introduces articles about scientific approaches on the rational design and development of antiviral drugs published in the March 2000 issue of the periodical 'Current Pharmaceutical Drug Design.' Design and evaluation of Hepatitis B virus inhibitors; Analysis of the catalytic cycle of HIV-1...

  • Comparison of tenofovir and entecavir in patients with chronic HBV infection. CEYLAN, B.; YARDIMCI, C.; FINCANCI, M.; EREN, G.; TOZALGAN, U.; MUDERRISOGLU, C.; AKKOYUNLU, Y. // European Review for Medical & Pharmacological Sciences;Sep2013, Vol. 17 Issue 18, p2467 

    BACKGROUND: Sustained suppression of serum HBV DNA levels with nucleos(t)ide analogues is the most important success obtained in the treatment of chronic HBV infection today. Tenofovir and entecavir provide more robust viral suppression. AIM: The aim of this study is to compare tenofovir and...

  • entecavir.  // Davis's Drug Guide for Nurses, 10th edition;2007, p451 

    The article presents a nursing guide to entecavir, an antiviral used to treat chronic hepatitis B. Indications and contraindications are mentioned. Adverse reactions to the drug are cited, including dizziness and headache. Nursing implications and desired outcomes are provided. Drug interactions...

  • Temozolomide.  // Reactions Weekly;4/28/2007, Issue 1149, p24 

    The article discusses a case report on hepatitis B reactivation in a 50-year-old man following treatment with temozolomide for the surgical resection of glioblastoma. It references a study by M. G. Chheda et al in the March 2007 issue of "Neurology." Information is presented on the daily dosage...

  • Antivirals.  // Reactions Weekly;Nov2014, Vol. 1526 Issue 1, p26 

    An abstract of the article "Safety of treatment with nucleoside/nucleotide analogues in chronic hepatitis B: Evaluation of ten-year period," by H. Bodur and colleagues is presented.

  • Reactivation of Hepatitis B Virus Replication Accompanied by Acute Hepatitis in Patients Receiving Highly Active Antiretroviral Therapy. Manegol, Christoph; Wywiol, Anett; Dietrich, Manfred; Chiwakata, Collins B.; Gunther, Stephan; Hannoun, Charles // Clinical Infectious Diseases;1/1/2001, Vol. 32 Issue 1, p144 

    Describes two case studies in which hepatitis B antibodies-positive patients experienced a sudden increase of hepatitis B virus replication during highly active antiretroviral therapy. Medical history of the patients; Clinical and virological course of patients; Treatment of hepatitis B...

  • lamivudine.  // Davis's Drug Guide for Nurses, 10th edition;2007, p692 

    The article presents a nursing guide for lamivudine, an antiretroviral, antiviral agent. It is indicated for a variety of infections: HIV infection and chronic hepatitis B infection. The mechanism of action and pharmacokinetics are discussed. Information is presented on adverse reactions/side...

  • Fanconi syndrome due to prolonged use of low-dose adefovir. Xiao-Bing Wang; Xiao-Chun Zhu; Xiao-Ying Huang; Wen-Jing Ye; Liang-Xing Wang // Journal of Research in Medical Sciences;Apr2015, Vol. 20 Issue 4, p416 

    Fanconi syndrome results from a generalized abnormality of the proximal tubules of the kidney and owing to phosphate depletion can cause hypophosphatemic osteomalacia. Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus replication but exhibits nephrotoxicity when administered at a...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics