TRPV1: a new target for treatment of visceral pain in IBS?

Holzer, Peter
July 2008
Gut;Jul2008, Vol. 57 Issue 7, p882
Academic Journal
The article provides information on the mechanisms and basic concepts of transient receptor potential vanilloid 1 (TRPV1) or capsaicin receptor. It was the one that lead to the discovery of a large family of closely related ion channels acting as molecular sensors for distinct spices. The ability of TRPV1 to become sensitised by proalgesic and inflammatory mediators has raised enormous interest for being a novel drug target for the treatment of chronic pain and hyperalgesia.


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