The cytokine interleukin 21: a new player in coeliac disease?

Meresse, Bertrand; Verdier, Julien; Cerf-Bensussan, Nadine
July 2008
Gut;Jul2008, Vol. 57 Issue 7, p879
Academic Journal
The article presents a study which focuses on the use of single-nucleotide polymorphisms. In this context, researchers demonstrate that interleukin 21 (IL21) expression is increased in the intestinal mucosa of patients with active coeliac disease (CD) but not that of treated patients. It has also been shown that IL21 is produced by CD4+ lamina propria T cells, a finding consistent with previous work indicating that this cytokine is exclusively produced by CD4+ T cells.


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