Human T Lymphotropic Virus Type 1 Infection and Gastric Cancer Development in Japan

Matsumoto, Satohiro; Yamasaki, Kazumi; Tsuji, Kenichiro; Shirahama, Satoshi
July 2008
Journal of Infectious Diseases;7/1/2008, Vol. 198 Issue 1, p10
Academic Journal
Background. The rate of human T lymphotropic virus type 1 (HTLV-1) positivity among residents of Kamigoto, Japan, is extremely high (15%). Although the rate of Helicobacter pylori positivity in Kamigoto is almost the same as that in other areas of Japan, the incidence of gastric cancer in Kamigoto is lower. This study examined whether HTLV-1 infection affects H. pylori infection and the development of gastric cancer. Methods. The study involved 5686 patients >40 years of age who provided serum specimens for HTLV-1 antibody testing during 1989-1992. A total of 1812 patients underwent gastric endoscopy during the follow-up period. Of these, 497 were HTLV-1 seropositive. Data for these patients were compared with those for 497 HTLV-1-seronegative control patients matched for age, sex, and follow-up duration. We followed these groups until 2003 and determined the cumulative incidence rate of gastric cancer. Results. The rate of H. pylori positivity was 61.7% in the HTLV-1-positive group and 71.6% in the HTLV-1-negative group (P=.07). Fourteen HTLV-1-positive patients (2.8%) had gastric cancer, compared with 35 patients (7.0%) in the HTLV-1-negative group (odds ratio, 0.38; 95% confidence interval, 0.21- 0.70; P=.0028). Conclusion. HTLV-1 infection likely reduces the risk of H. pylori infection and proliferation and, thereby, the risk of gastric cancer.


Related Articles

  • Predicting the development of gastric cancer from combining Helicobacter pylon antibodies and serum pepsinogen status: a prospective endoscopic cohort study. Watabe, H.; Mitsushima, T.; Yamaji, Y.; Okamoto, M.; Wada, R.; Kokubo, T.; Doi, H.; Yoshida, H.; Kawabe, T.; Omata, M. // Gut;Jun2005, Vol. 54 Issue 6, p764 

    Background and aim: Helicobacter pylon infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylon infection and gastric atrophy status. Subjects and methods: A total of 9293 participants in...

  • Helicobacter pyloriinfection and gastric cancer. Sugiyama, Toshiro; Asaka, Masahiro // Medical Electron Microscopy;Sep2004, Vol. 37 Issue 3, p149 

    Helicobacter pylori infection has an association with histological gastritis, gastric atrophy, gastric cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma in the stomach. Gastric cancer occurs in only a minority of infected individuals, however. Such clinical diversities are caused by...

  • Decrease in Ornithine Decarboxylase Activity after Eradication of Helicobacter pylori. Alam, Khalid; Arlow, Freda L.; Ma, Chan K.; Schubert, Timothy T. // American Journal of Gastroenterology;Jun1994, Vol. 89 Issue 6, p888 

    Objective: Our aim was to determine whether gastric mucosal ODC activity is altered after successful eradication of HP. Recent reports have suggested that Helicobacter pylori (HP) infection of the stomach is associated with the development of gastric cancer. Gastrointestinal cancers usually do...

  • HELICOBACTER PYLORI INFECTION AND THE DEVELOPMENT OF GASTRIC CANCER. Preda, Alina; Burada, F.; Soare, Cristina; Birca, Amelia; Moraru, E.; Cruce, M. // Annals of the Romanian Society for Cell Biology;2009, Vol. 14 Issue 2, p212 

    Helicobacter pylori, a Gram negative bacteria, is capable of modifying cell turnover in the interior of gastric glands, by influencing cell proliferation and apoptosis ratio. Gastric carcinogenesis is a complex, multifactorial process in which Helicobacter pylori persistence plays an important...

  • Helicobacter pylori and Cell Proliferation of the Gastric Mucosa: Possible Implications for Gastric Carcinogenesis. Bechi, Paolo; Balzi, Manuela; Becciolini, Aldo; Maugeri, Alessandra; Raggi, Claudia Casini; Amorosi, Andrea; Dei, Rosanna // American Journal of Gastroenterology;Feb1996, Vol. 91 Issue 2, p271 

    Objectives: Helicobacter pylori infection is recognized as a risk factor for gastric adenocarcinoma. "Mitogenesis increases mutagenesis," so the effects of H. pylori infection on the gastric mucosal proliferative compartment have been investigated. Methods: In 25 H....

  • Effect ofHelicobacter pyloriEradication in Patients with Chronic Idiopathic Thrombocytopenic Purpura–A Randomized Controlled Trial. Suzuki, Takayoshi; Matsushima, Masashi; Masui, Aya; Watanabe, Ken-ichi; Takagi, Atsushi; Ogawa, Yoshiaki; Shirai, Takayuki; Mine, Tetsuya // American Journal of Gastroenterology;Jun2005, Vol. 100 Issue 6, p1265 

    OBJECTIVE: Eradication ofHelicobacter pyloriwas reported to increase the platelet counts in someH. pylori-positive patients with chronic idiopathic thrombocytopenic purpura (cITP). However, the efficacy of the eradication was quite different according to the previous reports. To determine...

  • Effects of Helicobacter pylori infection on the expressions of Bax and Bcl-2 in patients with chronic gastritis and gastric cancer. Bartchewsky Jr., Waldemar; Martini, Mariana R.; Squassoni, Aline C.; Alvarez, Marisa C.; Ladeira, Marcelo S. P.; Salvatore, Daisy M. F.; Trevisan, Miriam A.; Pedrazzoli Jr., José; Ribeiro, Marcelo L.; Bartchewsky, Waldemar Jr; Pedrazzoli, José Jr // Digestive Diseases & Sciences;Jan2010, Vol. 55 Issue 1, p111 

    The aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive,...

  • Helicobacter pylori infection and relationship with gastric epithelial cell proliferation and apoptosis. GÜCİN, Zühal; ÇAKMAK, Tuğba; BAYYURT, Nizamettin; SALİH, Barik // Turkish Journal of Medical Sciences;Oct2013, Vol. 43 Issue 5, p739 

    Aim: To evaluate the effects of Helicobacter pylori on cell proliferation and apoptosis in gastric cancer (GC) both at tumoral and nontumoral sites and in gastritis. Materials and methods: Biopsies from 96 patients (gastric cancer = 52, gastritis = 44) were examined immunohistochemically and...

  • The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells. Hütz, Katharina; Mejías-Luque, Raquel; Farsakova, Katarina; Ogris, Manfred; Krebs, Stefan; Anton, Martina; Vieth, Michael; Schüller, Ulrich; Schneider, Marlon R.; Blum, Helmut; Wagner, Ernst; Jung, Andreas; Gerhard, Markus // Carcinogenesis;Apr2014, Vol. 35 Issue 4, p942 

    Gastric cancer (GC) is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with Helicobacter pylori, different environmental factors and genetic alterations are known to influence the risk of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics