Protective Role of DC-SIGN (CD209) Neck-Region Alleles with <5 Repeat Units in HIV-1 Transmission

Jing Zhang; Xinsheng Zhang; Jihua Fu; Zhenqiang Bi; Arheart, Kristopher L.; Barreiro, Luis B.; Quintana-Murci, Lluis; Pahwa, Savita; Huanliang Liu
July 2008
Journal of Infectious Diseases;7/1/2008, Vol. 198 Issue 1, p68
Academic Journal
To investigate the role that DC-SIGN neck-region length variation plays in HIV-1 transmission, we studied 530 HIV-1-positive and 341 HIV-1-negative individuals in China. The carrier frequency of a DC-SIGN allele with <5 repeat units in the neck-region was 0.9% in HIV-1-positive and 3.8% in HIV-1-negative individuals (P=.007), an observation suggesting that this DC-SIGN variation plays a role in HIV-1 transmission. These naturally occurring DC-SIGN neck-region variants were significantly more frequent in the Chinese population than in the US population (P<.001) and in a worldwide population (P=.006).


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