TITLE

Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat

AUTHOR(S)
Ruqiong Nie; Rui Xia; Xingwu Zhong; Zhengyuan Xia
PUB. DATE
October 2007
SOURCE
Canadian Journal of Physiology & Pharmacology;Oct2007, Vol. 85 Issue 10, p1012
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Oxidative stress may play a causative role in myocardial ischemia�reperfusion injury. However, it is a relatively understudied aspect regarding an optimal timing of antioxidant intervention during ischemia�reperfusion. The present study investigates the effect of different treatment regimens of Salvia miltiorrhiza (SM) herb extracts containing phenolic compounds that possess potent antioxidant properties on postischemic myocardial functional recovery in the setting of global myocardial ischemia and reperfusion. Langendorff-perfused rat hearts were subjected to 40 min of global ischemia at 37 �C followed by 60 min of reperfusion, and were randomly assigned into the untreated control and 2 SM-treated groups (n = 7 per group). In treatment 1 (SM1), 3 mg/mL of water soluble extract of SM was given for 10 min before ischemia and continued during ischemia through the aorta at a reduced flow rate of 60 �L/min, but not during reperfusion. In treatment 2 (SM2), SM (3 mg/mL) was given during the first 15 min of reperfusion. During ischemia, hearts in the control and SM2 groups were given physiological saline at 60 �L/min. The SM1 treatment reduced the production of 15-F2t-isoprostane, a specific index of oxidative stress-induced lipid peroxidation, during ischemia (94 � 20, 43 � 6, and 95 � 15 pg/mL in the coronary effluent in control, SM1, and SM2 groups, respectively; p < 0.05, SM1 vs. control or SM2) and postponed the onset of ischemic contracture. However, SM2, but not the SM1 regimen, significantly reduced 15-F2t-isoprostane production during early reperfusion and led to optimal postischemic myocardial functional recovery (left ventricular developed pressure 51 � 4, 46 � 4, and 60 � 6 mmHg in the control, SM1, and SM2 groups, respectively, at 60 min of reperfusion; p < 0.05, SM2 vs. control or SM1) and reduced myocardial infarct size as measured by triphenyltetrazolium chloride staining (26% � 2%, 22% � 2%, and 20% � 2% of the total area in the control, SM1, and SM2 groups, respectively, p < 0.05, SM2 vs. control). It is concluded that S. miltiorrhiza could be beneficial in the treatment of myocardial ischemic injury and the timing of administration seems important.
ACCESSION #
32756308

 

Related Articles

  • Persistent Oxidative Stress after Myocardial Infarction Treated by Percutaneous Coronary Intervention. NIKOLIC-HEITZLER, VJERAN; RABUZIN, FILIP; TATZBER, FRANZ; VRKIC, NADA; BULJ, NIKOLA; BOROVIC, SUZANA; WONISCH, WILLIBALD; SUNKO, BRANKA MAZUL; ZARKOVIC, NEVEN // Tohoku Journal of Experimental Medicine;Nov2006, Vol. 210 Issue 3, p247 

    Acute myocardial infarction causing cardiac ischemia is responsible for the majority of cardiac related deaths. Medical interventions that ensure rapid reperfusion, such as percutaneous coronary intervention, are aimed to allow myocardial re-oxygenation. However, this generates reactive oxygen...

  • Reduced Oxidative Stress in STEMI Patients Treated by Primary Percutaneous Coronary Intervention and with Antioxidant Therapy: A Systematic Review. Ekeløf, Sarah; Jensen, Svend; Rosenberg, Jacob; Gögenur, Ismail // Cardiovascular Drugs & Therapy;Apr2014, Vol. 28 Issue 2, p173 

    Purpose: Coronary reperfusion by primary percutaneous coronary intervention (PCI) has been established as an essential therapy of ST-elevation myocardial infarction (STEMI). Although the coronary intervention is undoubtedly beneficial, reperfusion itself can induce processes resulting in...

  • Deneysel Serebral Ä°skemi/Reperfüzyon Hasarında Kafeik Asit Fenetil Esterin Koruyucu Etkisi. Uzar, Ertuğrul; Acar, Abdullah; Fırat, Uğur; Evliyaoğlu, Osman; Alp, Harun; Tfek, Adnan; Yavuz, Celal; Demirtaş, Sinan; Taşdemir, Nebahat // Turkish Journal of Neurology / Turk Noroloji Dergisi;Sep2011, Vol. 17 Issue 3, p131 

    Objective: Because oxidative stress is related to cerebral ischemia/reperfusion (I/R) injury, modulation of oxygen free radical production may represent a new approach to the management of cerebral I/R. Caffeic acid phenethyl ester (CAPE) has been determined to have neuroprotective, antioxidant,...

  • Mitochondrial DNA deletions in coronary artery bypass grafting patients Levitsky, Sidney; Laurikka, Jari; Stewart, Robert D.; Campos, Christian T.; Lahey, Steven J.; McCully, James D. // European Journal of Cardio-Thoracic Surgery;Nov2003, Vol. 24 Issue 5, p777 

    Objective: Mitochondrial DNA (mitoDNA) deletions have been shown to increase with aging and ischemia and have been suggested to contribute to myocardial dysfunction. The purpose of this study was to determine the prevalence and specificity of mitoDNA deletions in coronary artery bypass patients....

  • Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced Oxidative Stress in Rats. Akondi, Butchi Raju; Challa, Siva Reddy; Akula, Annapurna // Journal of Reproduction & Infertility;Jul-Sep2011, Vol. 12 Issue 3, p209 

    Introduction: Testicular torsion and detorsion causes reperfusion injury which damages the testicular tissue and affects the quality of sperm. Deterioration in the quality of sperm worldwide is the recent scenario and one of its reasons is testicular ischemic/ reperfusion (IR) injury. Therefore...

  • Temporal and spatial characteristics of the area at risk investigated using computed tomography and T1-weighted magnetic resonance imaging. van der Pals, Jesper; Hammer-Hansen, Sophia; Nielles-Vallespin, Sonia; Kellman, Peter; Taylor, Joni; Kozlov, Shawn; Li-Yueh Hsu; Chen, Marcus Y.; Arai, Andrew E. // European Heart Journal - Cardiovascular Imaging;Nov2015, Vol. 16 Issue 11, p1232 

    Aims Cardiovascular magnetic resonance (CMR) imaging can measure the myocardial area at risk (AAR), but the technique has received criticism for inadequate validation. CMR commonly depicts an AAR that is wider than the infarct, which in turn would require a lateral perfusion gradient within the...

  • Inhibition of sPLA2-IIA, C-reactive Protein or Complement: New Therapy for Patients with Acute Myocardial Infarction? Krijnen, Paul A. J.; Meischl, Christof; Nijmeijer, Remco; Visser, Cees A.; Hack, C. Erik; Niessen, Hans W. M. // Cardiovascular & Haematological Disorders - Drug Targets;Jun2006, Vol. 6 Issue 2, p111 

    Reperfusion of ischemic myocardium after acute myocardial infarction (AMI) induces a local activation of inflammatory reactions that results in ischemia/reperfusion (I/R)-injury. I/R-injury contributes considerably to the total cell damage in the heart after AMI. Secretory phospolipase A2-IIA...

  • Management of the no-reflow phenomenon. Margetić, Eduard // Cardiologia Croatica;Mar/Apr2013, Vol. 8 Issue 3/4, p119 

    Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion strategy for treating acute ST-segment elevation myocardial infarction (STEMI). The main goals are to restore epicardial infarct-related artery (IRA) patency and achieve microvascular reperfusion as early as possible,...

  • Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs. Musiolik, Judith; Caster, Patrick van; Skyschally, Andreas; Boengler, Kerstin; Gres, Petra; Schulz, Rainer; Heusch, Gerd // Cardiovascular Research;Jan2010, Vol. 85 Issue 1, p110 

    Aims: Reperfusion is mandatory to salvage ischaemic myocardium from infarction, but also induces additional reperfusion injury and contributes to infarct size (IS). Gentle reperfusion (GR) has been proposed to attenuate reperfusion injury, but this remains contentious. We now investigated...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics