Biodistribution of titanium dioxide from biologic compartments

Olmedo, Daniel G.; Tasat, Deborah R.; Guglielmotti, María Beatriz; Cabrini, Rómulo Luis
September 2008
Journal of Materials Science: Materials in Medicine;Sep2008, Vol. 19 Issue 9, p3049
Academic Journal
The layer of titanium dioxide (TiO2) of the implant is chronically exposed to the internal electrolyte milieu in the peri-implant biological compartment. Corrosion results from electrochemical attack and ensuing gradual degradation of the metallic materials and is thus of biological interest when these biomaterials are employed in clinical implantology. Herein we evaluated and compared the chronic effect and the biodistribution of TiO2 administered subcutaneously or intraperitoneally. We propose that the compartmentalization of titanium in the area of subcutaneous injection would reproduce the biological compartment of the implant and its microenvironment from which metal ions could be released and migrate systemically. Potential TiO2 deposits were identified and characterized in skin, liver and lung by histological and EDX analyses. After both treatments, the skin, liver, and lungs exhibited histological evidence of TiO2 deposits. In order to characterize in situ macrophage-like cells, tissue sections were immunohistochemically stained for CD68. Tissue specimens from all organs assayed showed positive staining for anti-macrophage monoclonal antibody CD68 (PGM1). Despite the compartmentalization of titanium within nodular areas in rats treated subcutaneously, systemic migration occurred. We concluded that systemic migration of TiO2 occurred regardless of the administration route.


Related Articles

  • Cathodic electrodeposition of amorphous titanium oxide films from an alkaline solution bath. Lokhande, C. D.; Sun-Ki Min; Kwang-Deog Jung; Oh-Shim Joo // Journal of Materials Science;Jan2005, Vol. 40 Issue 2, p491 

    The article focuses on the Cathodic electrodeposition of amorphous titanium oxide films from an alkaline solution bath. Titanium oxide has been especially employed in making different electronic devices, including oxygen sensor, varistor, photoelectrode etc. A recent interest is focused on an...

  • Characterisation of calcium phosphate/titanium dioxide hybrid coatings. Boyd, A. R.; Burke, G. A.; Duffy, H.; Cairns, M. L.; O'Hare, P.; Meenan, B. J. // Journal of Materials Science: Materials in Medicine;Feb2008, Vol. 19 Issue 2, p485 

    The role of titanium dioxide (TiO2) as a means to engender enhanced stability into calcium phosphate (Ca-P) coatings has been well recognised. Several different methods have been used to create such Ca-P/TiO2 hybrid layers on a range of substrates. This paper reports the properties of a...

  • Synthesis, spectroscopy, and antibacterial activity of some transition metal complexes with tridentate (ONS) and bidentate (NN) donor Schiff bases. Panchal, P.; Patel, M. // Pharmaceutical Chemistry Journal;Oct2006, Vol. 40 Issue 10, p544 

    The complexes of a series of transition metal ions including Mn(II), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II) with salicylidene- o-aminothiophenol and bis(benzylidene)ethylenediamine or bis(acetophenone)ethylenediamine have been synthesized and characterized by elemental analyses, infrared...

  • Surface characterization and biocompatibility of titanium alloys implanted with nitrogen by Hardion+ technology. Gordin, D.; Gloriant, T.; Chane-Pane, V.; Busardo, D.; Mitran, V.; Höche, D.; Vasilescu, C.; Drob, S.; Cimpean, A. // Journal of Materials Science: Materials in Medicine;Dec2012, Vol. 23 Issue 12, p2953 

    In this study, the new Hardion+ micro-implanter technology was used to modify surface properties of biomedical pure titanium (CP-Ti) and Ti-6Al-4V ELI alloy by implantation of nitrogen ions. This process is based on the use of an electron cyclotron resonance ion source to produce a...

  • Agglomerates of Ultrafine Particles of Elemental Carbon and TiO[sub2] Induce Generation of Lipid Mediators in Alveolar Macrophages. Beck-Speier, Ingrid; Dayal, Niru; Karg, Erwin; Maier, Konrad L.; Roth, Christa; Ziesenis, Axel; Heyder, Joachim // Environmental Health Perspectives Supplements;Aug2001 Supplement 4, Vol. 109, p613 

    Examines the agglomerates of ultrafine particles from elemental carbon and titanium dioxide in alveolar macrophages. Respiratory burst activity of canine neutrophils; Role of lipid mediators in the promotion of lung tissue responses to air pollutants; Functions of alveolar macrophages.

  • Synergy Effect in the Combined Photodegradation of an Azo Dye by Titanium dioxide Photocatalysis and Photo-Fenton Oxidation. Bouras, Panagiotis; Lianos, Panagiotis // Catalysis Letters;Aug2008, Vol. 123 Issue 3/4, p220 

    Decolorization of the azo dye Basic Blue 41 was studied separately by photocatalysis in the presence of nanocrystalline Titania films or oxidation by Photo Fenton. Optimization procedures helped to determine the optimal quantity of TiO2 photocatalyst, hydrogen peroxide and Fe+2 ions. By...

  • Synthesis, Characterization with Photophysical and Ion Binding Properties of Ruthenium Complex. JIAN-FEI KONG; YU-JIE WANG; LU LIU; GUANG-JUN SHI; HUI-ZHEN LANG; CHUN-HUA ZHANG // Asian Journal of Chemistry;2015, Vol. 27 Issue 8, p2791 

    Host-guest chemistry has attracted much attention in the past several decades and the design of highly selective and sensitive receptors for metal ions is of great importance in the area of ion transport, chemosensing, biomedical as well as environmental applications. Herein we report the...

  • CONSIDERATIONS REGARDING THE IMPLICATIONS OF BIOMETALS IN MEDICINE. CÎRŢÎNĂ, Daniela // Fiability & Durability / Fiabilitate si Durabilitate;2016, Issue 2, p73 

    Many diseases are associated with changes in the concentrations of the metal ions from the tissues or body fluids. Complex control systems supervise and maintain the metalic ions in normal concentrations in the body. Influencing the systems responsible for the control of metal ions leads to...

  • Improved visible-light responsive photocatalytic activity of N and Si co-doped titanias. Ozaki, Hirotaka; Iwamoto, Shinji; Inoue, Masashi // Journal of Materials Science;Jun2007, Vol. 42 Issue 11, p4009 

    Thermal reaction of titanium tetraisopropoxide and tetraethyl orthosilicate in 1,4-butanediol afforded nanocrystalline silica-modified titanias having large surface area and superior thermal stability. In this study, the thus-obtained silica-modified titanias were treated in an NH3 flow at high...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics