Impact of FDG-PET/CT Fused Imaging on Tumor Volume Assessment of Head-and-Neck Squamous Cell Carcinoma: Intermethod and Interobserver Variations

Murakami, R.; Uozumi, H.; Hirai, T.; Nishimura, R.; Katsuragawa, S.; Shiraishi, S.; Toya, R.; Tashiro, K.; Kawanaka, K.; Oya, N.; Tomiguchi, S.; Yamashita, Y.
August 2008
Acta Radiologica;Aug2008, Vol. 49 Issue 6, p693
Academic Journal
Background: Although gross tumor volume (GTV) at the primary site can predict local control of head-and-neck squamous cell carcinoma (SCC) in patients who are treated with organ-preservation therapy, GTV assessment does not eliminate substantial interobserver variation. Purpose: To evaluate whether F-18-fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) fused imaging provides additional information for GTV assessment. Material and Methods: We obtained FDG-PET/CT fused images on 20 patients with head-and-neck SCC. All had undergone preoperative conventional workup, including contrast-enhanced CT and magnetic resonance imaging (MRI). The GTV of the primary tumors was designed by two independent observers who used routine clinical data. Observer A was a radiologist and observer B a radiation oncologist. GTV1 and GTV2 were designed without and with FDG-PET/CT, respectively. For geometric interobserver comparison, we calculated the concordance rate as the ratio of the intersection (Ax∩B) of the GTVs to their union (Ax∪B). Intermethod (GTV1 vs. GTV2) and interobserver (A vs. B) differences in the GTVs were assessed by Bland-Altman analysis and the Spearman rank-correlation test. The interobserver concordance rates for GTV1 and GTV2 were compared using a two-tailed paired-samples t test. Results: On FDG-PET/CT, all primary tumors were visualized. There was no systemic trend for a volume difference between GTV1 and GTV2. Although the 95% limits of agreement were wider for interobserver than intermethod differences, the 95% limits of interobserver agreement were narrower for GTV2 than GTV1. The mean interobserver concordance rate for GTV2 was higher than for GTV1 (54.5% vs. 39.1%, P=0.0002). Conclusion: FDG-PET/CT is a useful modality for consistent GTV assessment, which should not be used as a single modality but rather to obtain supplemental information in patients with head-and-neck SCC.


Related Articles

  • Pre-treatment maximal oesophageal wall thickness is independently associated with response to chemoradiotherapy in patients with T3–4 oesophageal squamous cell carcinoma. Li, Shau-Hsuan; Rau, Kun-Ming; Lu, Hung-I; Wang, Yu-Ming; Tien, Wan-Yu; Liang, Jiun-Lung; Lin, Wei-Che // European Journal of Cardio-Thoracic Surgery;Dec2012, Vol. 42 Issue 6, p958 

    OBJECTIVES Combined chemoradiotherapy with or without surgery is frequently performed as a curative treatment in patients with T3–4 locally advanced oesophageal squamous cell carcinoma. Computed tomography (CT) is frequently performed before and after chemoradiotherapy. The aim of this...

  • Nuclear medicine imaging for the assessment of primary and recurrent head and neck carcinoma using routinely available tracers. Vermeersch, Hubert; Loose, David; Ham, Hamphrey; Otte, Andreas; de Wiele, Christophe Van // European Journal of Nuclear Medicine & Molecular Imaging;2003, Vol. 30 Issue 12, p1689 

    This article reviews the literature on the use of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) and thallium-201, technetium99m sestamibi and technetium-99m tetrofosmin singlephoton emission tomography (SPET) for the diagnosis and staging of primary and recurrent squamous...

  • Sarcomatoid squamous cell carcinoma of uterine cervix: Pathology, imaging, and trreatment. Kumar, Milind; Bahl, Amit; Sharma, Daya Nand; Agarwal, Shipra; Halanaik, Dhanapathi; Kumarz, Rakesh; Rath, Goura Kishore // Journal of Cancer Research & Therapeutics;Jan2008, Vol. 4 Issue 1, p39 

    Sarcomatoid squamous cell carcinoma of the cervix is a rare tumor. Only 16 cases have so far been reported in literature. We report here one such tumor occurring in a 54-year-old postmenopausal woman. Our case report describes the clinical, pathological, and PET scan characteristics of this...

  • Magnetic Resonance Imaging Findings of Inverted Papilloma: Differential Diagnosis with Malignant Sinonasal Tumors. Maroldi, Roberto; Farina, Davide; Palvarini, Laura; Lombardi, Davide; Tomenzoli, Davide; Nicolai, Piero // American Journal of Rhinology;Sep/Oct2004, Vol. 18 Issue 5, p305 

    Background: Computed tomography and magnetic resonance imaging (MRI) are the techniques of choice for pretreatment staging in neoplasms of the sinonasal tract. In inverted papilloma (IP), the information provided by computed tomography regarding characterization of the lesion is rather...

  • Patient with Lingual Thyroid and Squamous Cell Carcinoma of the Tongue Base - Case Report. Čandrlić, Barbara; Pusić, Marin; Kukuljan, Melita; Cvjetković, Niko; Matana, Zrinka; Miletić, Damir // Collegium Antropologicum;Nov2012 Supplement 2, Vol. 36, p227 

    We demonstrate a rare case of lingual thyroid together with squamous cell carcinoma of the base of tongue. 54-year--old patient presented with left sided lymph node enlargement in regions II, III and IV, without any clinical symptoms. Physical examination revealed semicircular bulge at the base...

  • Basaloid squamous-cell carcinoma of the lung in a young woman. Nagakawa, Hiroyasu; Hiroshima, Kenzo; Takiguchi, Yuichi; Yatomi, Mari; Takahashi, Yoshihiko; Mikami, Makoto; Nakatani, Yukio; Kuriyama, Takayuki // International Journal of Clinical Oncology;Feb2006, Vol. 11 Issue 1, p66 

    We report a rare case of basaloid squamous cell carcinoma of the lung in a young Japanese woman. An 18-year-old woman presented with productive cough. Chest radiogram and computed tomography (CT) revealed a tumor in the left hilum accompanied by partial atelectasis of the left upper lobe and...

  • Imaging in laryngeal cancers. Joshi, Varsha M.; Wadhwa, Vineet; Mukherji, Suresh K. // Indian Journal of Radiology & Imaging;Aug2012, Vol. 22 Issue 3, p209 

    Imaging plays an important complementary role to clinical examination and endoscopic biopsy in the evaluation of laryngeal cancers. A vast majority of these cancers are squamous cell carcinomas (SCC). Cross.sectional imaging with contrast-enhanced computed tomography (CT) and magnetic resonance...

  • A comparison between CT and SPECT in detecting mandibular invasion by lower gingival squamous cell carcinoma. DUAN Qing-yun; JIA Mu-yun; ZHANG Xiong; YUAN Rong-tao; BU Ling-xue; SHANG Wei; ZHAO Jie; ZUO Shu-yao; JIN Xiao-ming; LI Ning-yi // Shanghai Journal of Stomatology;Oct2008, p471 

    PURPOSE: The purpose of this study is to compare the value of CT and SPECT in diagnosis of lower gingival carcinoma invading the mandible. METHODS: From February 2002 to October 2006, twenty-one patients with lower gingival squamous cell carcinoma were enrolled. The data of CT and SPECT were...

  • Advanced imaging applied to radiotherapy planning in head and neck cancer: a clinical review. K Newbold; M Partridge; G Cook; S A Sohaib; E Charles-Edwards; P Rhys-Evans; K Harrington; C Nutting // British Journal of Radiology;Jul2006, Vol. 79 Issue 943, p554 

    Head and neck squamous cell carcinoma represents an ideal model to investigate the application of recent advances in medical imaging to radiotherapy planning. Tumours usually remain localized, and are potentially curable with local radiation. The steep radiation dose-response relationships...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics